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Micromachines, Volume 10, Issue 6

2019 June - 78 articles

Cover Story: Tailor-made polymer scaffolds are excellent biomimetic platforms for tissue engineering. Yet accurate control over their architecture and integration of bio-actives that guide tissue development remain major challenges. Mesoporous vaterite CaCO3 crystals are superior sacrificial matrices for assembly of porous alginate scaffolds, providing a three-in-one solution for biopolymer cross-linking, precise control over scaffold structure, and adjusted localization of bio-actives pre-loaded into crystals at mild conditions. These intelligent hybrids belong to the 3rd generation of modern biomaterials. View this paper
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Articles (78)

  • Article
  • Open Access
16 Citations
4,662 Views
12 Pages

25 June 2019

We herein propose a new hydrodynamic mechanism of particle separation using dual-depth, lattice-patterned asymmetric microchannel networks. This mechanism utilizes three-dimensional (3D) laminar flow profiles formed at intersections of lattice channe...

  • Article
  • Open Access
7 Citations
5,899 Views
11 Pages

Lift-Off Assisted Patterning of Few Layers Graphene

  • Alessio Verna,
  • Simone Luigi Marasso,
  • Paola Rivolo,
  • Matteo Parmeggiani,
  • Marco Laurenti and
  • Matteo Cocuzza

25 June 2019

Graphene and 2D materials have been exploited in a growing number of applications and the quality of the deposited layer has been found to be a critical issue for the functionality of the developed devices. Particularly, Chemical Vapor Deposition (CV...

  • Review
  • Open Access
31 Citations
6,795 Views
20 Pages

Research Progress of Near-Infrared Fluorescence Immunoassay

  • Xiao-Hui Chang,
  • Jie Zhang,
  • Lin-Huan Wu,
  • Yan-Kun Peng,
  • Xiang-Ying Yang,
  • Xiao-Lin Li,
  • Ai-Jin Ma,
  • Jun-Cai Ma and
  • Guang-Quan Chen

24 June 2019

Near-infrared fluorescence probes (NIFPs) have been widely used in immunoassay, bio-imaging and medical diagnosis. We review the basic principles of near-infrared fluorescence and near-infrared detection technology, and summarize structures, properti...

  • Review
  • Open Access
161 Citations
20,480 Views
22 Pages

DEP-on-a-Chip: Dielectrophoresis Applied to Microfluidic Platforms

  • Haoqing Zhang,
  • Honglong Chang and
  • Pavel Neuzil

24 June 2019

Dielectric particles in a non-uniform electric field are subject to a force caused by a phenomenon called dielectrophoresis (DEP). DEP is a commonly used technique in microfluidics for particle or cell separation. In comparison with other separation...

  • Article
  • Open Access
15 Citations
4,051 Views
11 Pages

24 June 2019

A high performance doping-less tunneling field effect transistor with Ge/Si0.6Ge0.4/Si heterojunction (H-DLTFET) is proposed in this paper. Compared to the conventional doping-less tunneling field effect transistor (DLTFET), the source and channel re...

  • Article
  • Open Access
4 Citations
4,667 Views
12 Pages

Research on the Protrusions Near Silicon-Glass Interface during Cavity Fabrication

  • Meng Zhang,
  • Jian Yang,
  • Yurong He,
  • Fan Yang,
  • Yongmei Zhao,
  • Fen Xue,
  • Guowei Han,
  • Chaowei Si and
  • Jin Ning

23 June 2019

Taking advantage of good hermeticity, tiny parasitic capacitance, batch mode fabrication, and compatibility with multiple bonding techniques, the glass-silicon composite substrate manufactured by the glass reflow process has great potential to achiev...

  • Article
  • Open Access
7 Citations
3,782 Views
9 Pages

23 June 2019

This paper presents a shear-mode piezoelectric current sensing device for two-wire power cords in electric power grids. The piezoelectric heterostructure consists of a cymbal structure and a permalloy plate. The cymbal structure is constructed from a...

  • Article
  • Open Access
21 Citations
4,965 Views
10 Pages

22 June 2019

Nowadays, the environmental issues surrounding the production of electronics, from the perspectives of both the materials used and the manufacturing process, are of major concern. The usage, storage, disposal protocol and volume of waste material con...

  • Review
  • Open Access
13 Citations
6,885 Views
19 Pages

22 June 2019

The tumor microenvironment (TME) is composed of dynamic and complex networks composed of matrix substrates, extracellular matrix (ECM), non-malignant cells, and tumor cells. The TME is in constant evolution during the disease progression, most notabl...

  • Review
  • Open Access
25 Citations
12,319 Views
22 Pages

Micro/Nano Technologies for High-Density Retinal Implant

  • Qi Zeng,
  • Saisai Zhao,
  • Hangao Yang,
  • Yi Zhang and
  • Tianzhun Wu

22 June 2019

During the past decades, there have been leaps in the development of micro/nano retinal implant technologies, which is one of the emerging applications in neural interfaces to restore vision. However, higher feedthroughs within a limited space are ne...

  • Article
  • Open Access
19 Citations
9,539 Views
12 Pages

A MEMS-Based Quad-Wavelength Hybrid Plasmonic–Pyroelectric Infrared Detector

  • Anh Tung Doan,
  • Takahiro Yokoyama,
  • Thang Duy Dao,
  • Satoshi Ishii,
  • Akihiko Ohi,
  • Toshihide Nabatame,
  • Yoshiki Wada,
  • Shigenao Maruyama and
  • Tadaaki Nagao

21 June 2019

Spectrally selective detection is of crucial importance for diverse modern spectroscopic applications such as multi-wavelength pyrometry, non-dispersive infrared gas sensing, biomedical analysis, flame detection, and thermal imaging. This paper repor...

  • Feature Paper
  • Review
  • Open Access
33 Citations
6,762 Views
21 Pages

21 June 2019

Nanoparticles (NPs) have found a wide range of applications in clinical therapeutic and diagnostic fields. However, currently most NPs are still in the preclinical evaluation phase with few approved for clinical use. Microfluidic systems can simulate...

  • Article
  • Open Access
15 Citations
5,374 Views
18 Pages

21 June 2019

Micromotors show many advantages in practical applications, including small size, large push-to-weight ratio, and low power consumption. Micromotors have been widely used in a variety of applications, including cell manipulation, payload delivery, an...

  • Article
  • Open Access
23 Citations
7,794 Views
12 Pages

MEMS-Based Wavelength-Selective Bolometers

  • Thang Duy Dao,
  • Anh Tung Doan,
  • Satoshi Ishii,
  • Takahiro Yokoyama,
  • Handegård Sele Ørjan,
  • Dang Hai Ngo,
  • Tomoko Ohki,
  • Akihiko Ohi,
  • Yoshiki Wada and
  • Tadaaki Nagao
  • + 3 authors

21 June 2019

We propose and experimentally demonstrate a compact design for membrane-supported wavelength-selective infrared (IR) bolometers. The proposed bolometer device is composed of wavelength-selective absorbers functioning as the efficient spectroscopic IR...

  • Article
  • Open Access
22 Citations
7,269 Views
12 Pages

20 June 2019

This paper presents the design, fabrication, and characterization of a highly sensitive, single drive multi-axis gyroscope. The multi-axis gyroscope allows for a wide bandwidth in all three axes (X, Y, Z) and exhibits high linearity. The fabricated m...

  • Article
  • Open Access
6 Citations
4,175 Views
10 Pages

20 June 2019

An area-efficient non-volatile flip flop (NVFF) is proposed. Two minimum-sized Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) and two magnetic tunnel junction (MTJ) devices are added on top of a conventional D flip-flop for temporary stor...

  • Review
  • Open Access
79 Citations
15,897 Views
25 Pages

20 June 2019

Recently, droplet-based microfluidic systems have been widely used in various biochemical and molecular biological assays. Since this platform technique allows manipulation of large amounts of data and also provides absolute accuracy in comparison to...

  • Review
  • Open Access
11 Citations
5,272 Views
18 Pages

19 June 2019

Bioimaging generally indicates imaging techniques that acquire biological information from living forms. Among different imaging techniques, optical microscopy plays a predominant role in observing tissues, cells and biomolecules. Along with the fast...

  • Review
  • Open Access
117 Citations
13,598 Views
26 Pages

19 June 2019

The significant advance of power electronics in today’s market is calling for high-performance power conversion systems and MEMS devices that can operate reliably in harsh environments, such as high working temperature. Silicon-carbide (SiC) po...

  • Article
  • Open Access
3 Citations
3,944 Views
14 Pages

Research on an On-Chip MEMS Based Safety and Arming Device with a Mechanical Encryption System

  • Kuang Fang,
  • Tengjiang Hu,
  • Xueting Zhang,
  • Zhiming Zhang,
  • Xiaohua Jiang and
  • Yulong Zhao

19 June 2019

The design and characterization of microelectromechanical systems (MEMS) based on-chip SAD (Safety and Arming Device) are proposed. An encryption system has been integrated into the device to enhance its reliability during the electromagnetic interfe...

  • Feature Paper
  • Review
  • Open Access
63 Citations
11,438 Views
34 Pages

Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology

  • Lena Gorgannezhad,
  • Helen Stratton and
  • Nam-Trung Nguyen

19 June 2019

Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this research area has had a broad range of applications. Novel and innovative strategies for detection and identification of bacterial nucleic acids are impo...

  • Article
  • Open Access
32 Citations
7,007 Views
10 Pages

Microfluidic Cell Trapping for Single-Cell Analysis

  • Bing Deng,
  • Heyi Wang,
  • Zhaoyi Tan and
  • Yi Quan

19 June 2019

The single-cell capture microfluidic chip has many advantages, including low cost, high throughput, easy manufacturing, integration, non-toxicity and good stability. Because of these characteristics, the cell capture microfluidic chip is increasingly...

  • Article
  • Open Access
20 Citations
5,251 Views
7 Pages

17 June 2019

We have fabricated Cu-based micropatterns in an ambient environment using femtosecond laser direct writing to reduce a glyoxylic acid Cu complex spin-coated onto a glass substrate. To do this, we scanned a train of focused femtosecond laser pulses ov...

  • Article
  • Open Access
19 Citations
5,598 Views
11 Pages

Advanced Graphene-Based Transparent Conductive Electrodes for Photovoltaic Applications

  • Susana Fernández,
  • Alberto Boscá,
  • Jorge Pedrós,
  • Andrea Inés,
  • Montserrat Fernández,
  • Israel Arnedo,
  • José Pablo González,
  • Marina de la Cruz,
  • David Sanz and
  • Javier Martínez
  • + 6 authors

17 June 2019

New architectures of transparent conductive electrodes (TCEs) incorporating graphene monolayers in different configurations have been explored with the aim to improve the performance of silicon-heterojunction (SHJ) cell front transparent contacts. In...

  • Article
  • Open Access
11 Citations
4,616 Views
9 Pages

17 June 2019

In this paper, we proposed near-infrared spectroscopy based on a Si photodetector equipped with a gold grating and extended the measurable wavelength range to cover 1200–1600 nm by improving a spectrum derivation procedure. In the spectrum deri...

  • Article
  • Open Access
27 Citations
5,555 Views
19 Pages

The Effect of Electrolytic Jet Orientation on Machining Characteristics in Jet Electrochemical Machining

  • Xinmin Zhang,
  • Xudong Song,
  • Pingmei Ming,
  • Xinchao Li,
  • Yongbin Zeng and
  • Jintao Cai

17 June 2019

Jet electrochemical machining (Jet-ECM) is a significant prospective electrochemical machining process for the fabrication of micro-sized features. Traditionally and normally, the Jet-ECM process is carried out with its electrolytic jet being vertica...

  • Feature Paper
  • Article
  • Open Access
5 Citations
4,847 Views
13 Pages

16 June 2019

This paper reports a biomimetic microfluidic device capable of reconstituting physiological physical microenvironments in lungs during fetal development for cell culture. The device integrates controllability of both hydrostatic pressure and cyclic s...

  • Article
  • Open Access
31 Citations
7,800 Views
9 Pages

Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers

  • Shinako Bansai,
  • Takashi Morikura,
  • Hiroaki Onoe and
  • Shogo Miyata

15 June 2019

Engineering of the skeletal muscles has attracted attention for the restoration of damaged muscles from myopathy, injury, and extraction of malignant tumors. Reconstructing a three-dimensional muscle using living cells could be a promising approach....

  • Feature Paper
  • Article
  • Open Access
14 Citations
5,930 Views
9 Pages

14 June 2019

We modeled a kirigami structure by considering the influence of non-uniform deforming cuts in order to theoretically design the mechanical characteristics of the structure. It is known that the end regions of kirigami structures are non-uniformly def...

  • Article
  • Open Access
2 Citations
4,850 Views
10 Pages

14 June 2019

For mounting electronic components through contact pressure using elastic adhesives, a high contact resistance is an inevitable issue in achieving solderless wiring in a low-temperature and low-cost process. To decrease the contact resistance, we inv...

  • Review
  • Open Access
80 Citations
10,786 Views
19 Pages

Nanomaterials-Based Electrochemical Immunosensors

  • Zhenguo Zhang,
  • Yulin Cong,
  • Yichun Huang and
  • Xin Du

14 June 2019

With the development of nanomaterials and sensor technology, nanomaterials-based electrochemical immunosensors have been widely employed in various fields. Nanomaterials for electrode modification are emerging one after another in order to improve th...

  • Article
  • Open Access
10 Citations
4,545 Views
16 Pages

Chaotic Micromixer Based on 3D Horseshoe Transformation

  • He Zhang,
  • Xin Li,
  • Rongyan Chuai and
  • Yingjie Zhang

14 June 2019

To improve the efficiency of mixing under laminar flow with a low Reynolds number (Re), a novel three-dimensional Horseshoe Transformation (3D HT) was proposed as the basis for the design of a micromixer. Compared with the classical HT, the Lyapunov...

  • Article
  • Open Access
14 Citations
4,626 Views
14 Pages

Fabrication of Hydrophilic Surface on Rigid Gas Permeable Contact Lenses to Enhance the Wettability Using Ultraviolet Laser System

  • Hsin-Yi Tsai,
  • Yu-Chen Hsieh,
  • Yu-Hsuan Lin,
  • Han-Chao Chang,
  • Yu-Hsiang Tang and
  • Kuo-Cheng Huang

13 June 2019

The widely used rigid gas permeable (RGP) contact lenses provide higher oxygen permeability and tear exchange rate than do soft contact lenses. However, their wettability warrants improvement to enhance the wearing comfort. This study used UV laser (...

  • Review
  • Open Access
93 Citations
10,136 Views
29 Pages

Microfluidic Technology for Clinical Applications of Exosomes

  • Florina S. Iliescu,
  • Danilo Vrtačnik,
  • Pavel Neuzil and
  • Ciprian Iliescu

12 June 2019

Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases...

  • Article
  • Open Access
18 Citations
6,304 Views
15 Pages

12 June 2019

Deterministic lateral displacement (DLD) technology has great potential for the separation, enrichment, and sorting of red blood cells (RBCs). This paper presents a numerical simulation of the motion of RBCs using DLD devices with different pillar sh...

  • Article
  • Open Access
14 Citations
4,499 Views
16 Pages

11 June 2019

Aptamer functionalized graphene field effect transistor (apta-GFET) is a versatile bio-sensing platform. However, the chemical inertness of graphene is still an obstacle for its large-scale applications and commercialization. In this work, reduced ca...

  • Article
  • Open Access
9 Citations
3,352 Views
9 Pages

Plasma-Induced Bubble Microjet Metallization of Elastomer

  • Keita Ichikawa,
  • Natsumi Basaki,
  • Yu Yamashita and
  • Yoko Yamanishi

11 June 2019

As the development of flexible materials and advanced materials progresses, innovative wiring methods for these materials are attracting attention. In this study, we investigated a new wiring technology using plasma-induced microbubbles for elastomer...

  • Review
  • Open Access
30 Citations
6,457 Views
23 Pages

Application of Microfluidic Chips in Separation and Analysis of Extracellular Vesicles in Liquid Biopsy for Cancer

  • Jin Lu,
  • Jiushen Pang,
  • Ying Chen,
  • Qi Dong,
  • Jiahao Sheng,
  • Yong Luo,
  • Yao Lu,
  • Bingcheng Lin and
  • Tingjiao Liu

11 June 2019

Extracellular vesicles (EVs) are becoming a promising biomarker in liquid biopsy of cancer. Separation EV from cell culture medium or biofluids with high purity and quality remains a technique challenge. EV manipulation techniques based on microfluid...

  • Review
  • Open Access
17 Citations
7,485 Views
19 Pages

Towards On-Chip Self-Referenced Frequency-Comb Sources Based on Semiconductor Mode-Locked Lasers

  • Marcin Malinowski,
  • Ricardo Bustos-Ramirez,
  • Jean-Etienne Tremblay,
  • Guillermo F. Camacho-Gonzalez,
  • Ming C. Wu,
  • Peter J. Delfyett and
  • Sasan Fathpour

11 June 2019

Miniaturization of frequency-comb sources could open a host of potential applications in spectroscopy, biomedical monitoring, astronomy, microwave signal generation, and distribution of precise time or frequency across networks. This review article p...

  • Article
  • Open Access
6 Citations
4,790 Views
10 Pages

High-Throughput Platform for Efficient Chemical Transfection, Virus Packaging, and Transduction

  • Jianxiong Zhang,
  • Yawei Hu,
  • Xiaoqing Wang,
  • Peng Liu and
  • Xiaofang Chen

10 June 2019

Intracellular gene delivery is normally required to study gene functions. A versatile platform able to perform both chemical transfection and viral transduction to achieve efficient gene modification in most cell types is needed. Here we demonstrated...

  • Article
  • Open Access
14 Citations
4,584 Views
11 Pages

Memristor Neural Network Training with Clock Synchronous Neuromorphic System

  • Sumin Jo,
  • Wookyung Sun,
  • Bokyung Kim,
  • Sunhee Kim,
  • Junhee Park and
  • Hyungsoon Shin

Memristor devices are considered to have the potential to implement unsupervised learning, especially spike timing-dependent plasticity (STDP), in the field of neuromorphic hardware research. In this study, a neuromorphic hardware system for multilay...

  • Article
  • Open Access
6 Citations
3,808 Views
16 Pages

Efficient Fabrication Process of Ordered Metal Nanodot Arrays for Infrared Plasmonic Sensor

  • Masahiko Yoshino,
  • Yusuke Kubota,
  • Yuki Nakagawa and
  • Motoki Terano

In this paper, a simple process to fabricate ordered Au nanodot arrays up to 520 nm in diameter that respond to infrared light is developed, and the feasibility of its application to infrared plasmonic sensors is shown. The developed process utilizes...

  • Article
  • Open Access
34 Citations
4,961 Views
10 Pages

We developed an epithelial cell adhesion molecule (EpCAM)-based positive method and CD45/CD66b-based negative method for isolating circulating tumor cells (CTCs) by lateral magnetophoresis. The CTC recovery rate, white blood cell depletion rate, and...

  • Article
  • Open Access
42 Citations
12,418 Views
14 Pages

A MEMS Micro-g Capacitive Accelerometer Based on Through-Silicon-Wafer-Etching Process

  • Kang Rao,
  • Xiaoli Wei,
  • Shaolin Zhang,
  • Mengqi Zhang,
  • Chenyuan Hu,
  • Huafeng Liu and
  • Liang-Cheng Tu

This paper presents a micromachined micro-g capacitive accelerometer with a silicon-based spring-mass sensing element. The displacement changes of the proof mass are sensed by an area-variation-based capacitive displacement transducer that is formed...

  • Article
  • Open Access
2 Citations
4,280 Views
13 Pages

Second-order vector modes, possessing doughnut-shaped intensity distribution with unique polarization, are widely utilized in material micromachining, optical tweezers, and high-resolution microscopy. Since the hollow-core fiber can act as a flexible...

  • Article
  • Open Access
32 Citations
6,199 Views
13 Pages

In this paper, a theoretical model of the critical depth of cut of nanoscratching on a 4H-SiC single crystal with a Berkovich indenter is proposed, and a series of scratch tests in a nanomechanical test system was performed. Through nanoindentation e...

  • Article
  • Open Access
12 Citations
4,471 Views
15 Pages

The nanoprecipitation of polymers is of great interest in biological and medicinal applications. Many approaches are available, but few generalized methods can fabricate structurally different biocompatible polymers into nanosized particles with a na...

  • Article
  • Open Access
11 Citations
4,229 Views
21 Pages

A Lumped Mass Model for Circular Micro-Resonators in Coriolis Vibratory Gyroscopes

  • Xukai Ding,
  • Jia JIA,
  • Zhengcheng Qin,
  • Zhihu Ruan,
  • Liye Zhao and
  • Hongsheng Li

Coriolis vibratory gyroscopes (CVGs) with circular micro-resonators, such as hemispherical, ring, and disk resonators, exhibit excellent performances and have extraordinary potential. This paper discusses a generalized lumped mass model for both 3D a...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,884 Views
21 Pages

This study investigated slip and magnetic attraction effects in a skid-steered magnetic-wheeled microrobot. The dynamics of the microrobot were derived by considering the slip and magnetic attraction of the wheels. In addition, the slip characteristi...

  • Article
  • Open Access
10 Citations
3,727 Views
8 Pages

The range of fundamental phenomena and applications achievable by metamaterials (MMs) can be significantly extended by dynamic control over the optical response. A mid-infrared tunable absorber which consists of lithography-free planar multilayered d...

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Micromachines - ISSN 2072-666X