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Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology

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Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, Australia
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School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, Australia
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Author to whom correspondence should be addressed.
Micromachines 2019, 10(6), 408; https://doi.org/10.3390/mi10060408
Received: 27 May 2019 / Revised: 14 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this research area has had a broad range of applications. Novel and innovative strategies for detection and identification of bacterial nucleic acids are important for practical applications. Microfluidics is an emerging technology that only requires small amounts of liquid samples. Microfluidic devices allow for rapid advances in microbiology, enabling access to methods of amplifying nucleic acid molecules and overcoming difficulties faced by conventional. In this review, we summarize the recent progress in microfluidics-based polymerase chain reaction devices for the detection of nucleic acid biomarkers. The paper also discusses the recent development of isothermal nucleic acid amplification and droplet-based microfluidics devices. We discuss recent microfluidic techniques for sample preparation prior to the amplification process. View Full-Text
Keywords: bacterial nucleic acid; microfluidic; PCR; LAMP; droplet bacterial nucleic acid; microfluidic; PCR; LAMP; droplet
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MDPI and ACS Style

Gorgannezhad, L.; Stratton, H.; Nguyen, N.-T. Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology. Micromachines 2019, 10, 408.

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