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Viruses, Volume 14, Issue 8

August 2022 - 248 articles

Cover Story: Many of the proteins made by RNA viruses, including Coxsackievirus, Norovirus and SARS-CoV-2, end in a C-terminal ΦQ motif because they are excised by 3C protease from a precursor polyprotein. In this issue, Luptak and colleagues reveal that this ΦQ motif is a C-terminal degron recognized by the E3 ligase TRIM7. TRIM7 targets ΦQ-containing proteins for proteasomal degradation in a mechanism reminiscent of the N-end rule and which allows it to potently inhibit viral replication. However, as TRIM7 is not immune regulated and has restricted tissue expression, its natural function may not be as a viral restriction factor. View this paper
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Articles (248)

  • Article
  • Open Access
6 Citations
3,538 Views
24 Pages

COVID-19 Modeling Outcome versus Reality in Sweden

  • Marcus Carlsson and
  • Cecilia Söderberg-Nauclér

22 August 2022

It has been very difficult to predict the development of the COVID-19 pandemic based on mathematical models for the spread of infectious diseases, and due to major non-pharmacological interventions (NPIs), it is still unclear to what extent the model...

  • Article
  • Open Access
25 Citations
4,158 Views
17 Pages

IHNV Infection Induces Strong Mucosal Immunity and Changes of Microbiota in Trout Intestine

  • Zhenyu Huang,
  • Mengting Zhan,
  • Gaofeng Cheng,
  • Ruiqi Lin,
  • Xue Zhai,
  • Haiou Zheng,
  • Qingchao Wang,
  • Yongyao Yu and
  • Zhen Xu

22 August 2022

The fish intestinal mucosa is among the main sites through which environmental microorganisms interact with the host. Therefore, this tissue not only constitutes the first line of defense against pathogenic microorganisms but also plays a crucial rol...

  • Article
  • Open Access
7 Citations
4,517 Views
16 Pages

Chikungunya Virus E2 Structural Protein B-Cell Epitopes Analysis

  • João Paulo da Cruz Silva,
  • Marielton dos Passos Cunha,
  • Shahab Zaki Pour,
  • Vitor Renaux Hering,
  • Daniel Ferreira de Lima Neto and
  • Paolo Marinho de Andrade Zanotto

22 August 2022

The Togaviridae family comprises a large and diverse group of viruses responsible for recurrent outbreaks in humans. Within this family, the Chikungunya virus (CHIKV) is an important Alphavirus in terms of morbidity, mortality, and economic impact on...

  • Article
  • Open Access
7 Citations
3,744 Views
25 Pages

Predicting Epitope Candidates for SARS-CoV-2

  • Akshay Agarwal,
  • Kristen L. Beck,
  • Sara Capponi,
  • Mark Kunitomi,
  • Gowri Nayar,
  • Edward Seabolt,
  • Gandhar Mahadeshwar,
  • Simone Bianco,
  • Vandana Mukherjee and
  • James H. Kaufman

21 August 2022

Epitopes are short amino acid sequences that define the antigen signature to which an antibody or T cell receptor binds. In light of the current pandemic, epitope analysis and prediction are paramount to improving serological testing and developing v...

  • Article
  • Open Access
10 Citations
3,808 Views
23 Pages

21 August 2022

The diffusion of viruses at the cell membrane is essential to reach a suitable entry site and initiate subsequent internalization. Although many viruses take advantage of glycosaminoglycans (GAG) to bind to the cell surface, little is known about the...

  • Article
  • Open Access
7 Citations
3,693 Views
19 Pages

Properties of Adenovirus Vectors with Increased Affinity to DSG2 and the Potential Benefits of Oncolytic Approaches and Gene Therapy

  • Nora A. Bahlmann,
  • Raphael L. Tsoukas,
  • Sebastian Erkens,
  • Hongjie Wang,
  • Franziska Jönsson,
  • Malik Aydin,
  • Ella A. Naumova,
  • André Lieber,
  • Anja Ehrhardt and
  • Wenli Zhang

21 August 2022

Carcinomas are characterized by a widespread upregulation of intercellular junctions that create a barrier to immune response and drug therapy. Desmoglein 2 (DSG2) represents such a junction protein and serves as one adenovirus receptor. Importantly,...

  • Article
  • Open Access
18 Citations
4,269 Views
14 Pages

ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine

  • Elizabeth Ramirez-Medina,
  • Elizabeth Vuono,
  • Sarah Pruitt,
  • Ayushi Rai,
  • Nallely Espinoza,
  • Alyssa Valladares,
  • Edward Spinard,
  • Ediane Silva,
  • Lauro Velazquez-Salinas and
  • Douglas P. Gladue
  • + 1 author

21 August 2022

African swine fever virus (ASFV) is the etiological agent of a swine pandemic affecting a large geographical area extending from Central Europe to Asia. The viral disease was also recently identified in the Dominican Republic and Haiti. ASFV is a str...

  • Article
  • Open Access
1 Citations
2,529 Views
15 Pages

HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men

  • Christophe Vanpouille,
  • Alan Wells,
  • Jennifer M. Dan,
  • Stephen A. Rawlings,
  • Susan Little,
  • Wendy Fitzgerald,
  • Leonid Margolis and
  • Sara Gianella

21 August 2022

Objective: CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antir...

  • Article
  • Open Access
7 Citations
2,560 Views
12 Pages

21 August 2022

We have limited knowledge about the course of the European catfish virus (ECV) infection in different age groups of wels catfish (Silurus glanis). The results of this study demonstrate that an ECV strain isolated from the brown bullhead (Ameiurus neb...

  • Article
  • Open Access
9 Citations
3,761 Views
22 Pages

21 August 2022

Grapevine leafroll-associated virus 3 (GLRaV-3) is one of the most important viruses affecting global grape and wine production. GLRaV-3 is the chief agent associated with grapevine leafroll disease (GLRD), the most prevalent and economically destruc...

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Viruses - ISSN 1999-4915