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Viruses, Volume 14, Issue 8

August 2022 - 248 articles

Cover Story: Many of the proteins made by RNA viruses, including Coxsackievirus, Norovirus and SARS-CoV-2, end in a C-terminal ΦQ motif because they are excised by 3C protease from a precursor polyprotein. In this issue, Luptak and colleagues reveal that this ΦQ motif is a C-terminal degron recognized by the E3 ligase TRIM7. TRIM7 targets ΦQ-containing proteins for proteasomal degradation in a mechanism reminiscent of the N-end rule and which allows it to potently inhibit viral replication. However, as TRIM7 is not immune regulated and has restricted tissue expression, its natural function may not be as a viral restriction factor. View this paper
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Articles (248)

  • Article
  • Open Access
35 Citations
4,834 Views
26 Pages

Induction of Systemic Resistance to Tobacco mosaic virus in Tomato through Foliar Application of Bacillus amyloliquefaciens Strain TBorg1 Culture Filtrate

  • Ahmed Abdelkhalek,
  • Dalia G. Aseel,
  • Lóránt Király,
  • András Künstler,
  • Hassan Moawad and
  • Abdulaziz A. Al-Askar

20 August 2022

The application of microbe-derived products as natural biocontrol agents to boost systemic disease resistance to virus infections in plants is a prospective strategy to make agriculture more sustainable and environmentally friendly. In the current st...

  • Article
  • Open Access
6 Citations
2,994 Views
14 Pages

20 August 2022

Rhinoviruses (RVs) constitute a substantial public health burden. To evaluate their abundance and genetic diversity in pediatric patients, RV RNA in respiratory samples was assessed using real-time RT-PCR and partial nucleic acid sequencing of viral...

  • Article
  • Open Access
3 Citations
4,053 Views
12 Pages

Self-Assembly of Porcine Parvovirus Virus-like Particles and Their Application in Serological Assay

  • Yanfei Gao,
  • Haiwei Wang,
  • Shanghui Wang,
  • Mingxia Sun,
  • Zheng Fang,
  • Xinran Liu,
  • Xuehui Cai and
  • Yabin Tu

20 August 2022

Porcine parvovirus (PPV) is widely prevalent in pig farms. PPV is closely related to porcine respiratory disease complex (PRDC) and porcine circovirus disease (PCVD), which seriously threatens the healthy development of the pig industry. Although com...

  • Article
  • Open Access
18 Citations
4,276 Views
20 Pages

Pharmacophore-Model-Based Drug Repurposing for the Identification of the Potential Inhibitors Targeting the Allosteric Site in Dengue Virus NS5 RNA-Dependent RNA Polymerase

  • Sanjay Kumar,
  • Leena H. Bajrai,
  • Arwa A. Faizo,
  • Aiah M. Khateb,
  • Areej A. Alkhaldy,
  • Rashmi Rana,
  • Esam I. Azhar and
  • Vivek Dhar Dwivedi

20 August 2022

Dengue virus (DENV) is the causative agent of DENV infection. To tackle DENV infection, the development of therapeutic molecules as direct-acting antivirals (DAAs) has been demonstrated as a truly effective approach. Among various DENV drug targets,...

  • Article
  • Open Access
2 Citations
3,108 Views
11 Pages

Complete Genome Analysis and Animal Model Development of Fowl Adenovirus 8b

  • Aijing Liu,
  • Yu Zhang,
  • Jing Wang,
  • Hongyu Cui,
  • Xiaole Qi,
  • Changjun Liu,
  • Yanping Zhang,
  • Kai Li,
  • Li Gao and
  • Xiaomei Wang
  • + 2 authors

20 August 2022

Inclusion body hepatitis (IBH), hydropericardium syndrome, and gizzard erosion associated with fowl adenovirus (FAdV) infection have caused notable economic losses worldwide. In 2020, severe IBH was observed in a layer chicken farm in Hebei Province,...

  • Article
  • Open Access
13 Citations
3,592 Views
15 Pages

Rotavirus C Replication in Porcine Intestinal Enteroids Reveals Roles for Cellular Cholesterol and Sialic Acids

  • Yusheng Guo,
  • Sergei Raev,
  • Maryssa K. Kick,
  • Molly Raque,
  • Linda J. Saif and
  • Anastasia N. Vlasova

20 August 2022

Rotaviruses (RVs) are a significant cause of severe diarrheal illness in infants and young animals, including pigs. Group C rotavirus (RVC) is an emerging pathogen increasingly reported in pigs and humans worldwide, and is currently recognized as the...

  • Review
  • Open Access
6 Citations
4,419 Views
13 Pages

20 August 2022

Cigarette smoke (CS) is a significant public health problem and a leading risk factor for the development of chronic obstructive pulmonary disease (COPD) in the developed world. Respiratory viral infections, such as the influenza A virus (IAV), are a...

  • Article
  • Open Access
10 Citations
4,243 Views
12 Pages

19 August 2022

(1) Background: CMV and EBV co-infections can affect the HIV disease progression by modulating the immune system. The disease dynamics can differ in HIV-positive adults and children. In Pakistan, HIV is rapidly expanding, especially in children; howe...

  • Article
  • Open Access
38 Citations
4,391 Views
23 Pages

19 August 2022

Solid organ transplant (SOT) recipients are at greater risk of coronavirus disease 2019 (COVID-19) and have attenuated response to vaccinations. In the present meta-analysis, we aimed to evaluate the serologic response to the COVID-19 vaccine in SOT...

  • Article
  • Open Access
5 Citations
2,763 Views
16 Pages

19 August 2022

Umbraviruses are a special class of plant viruses that do not encode any viral structural proteins. Here, a novel umbravirus that has been tentatively named Paederia scandens chlorosis yellow virus (PSCYV) was discovered through RNA-seq in Paederia s...

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Viruses - ISSN 1999-4915