Table of Contents
Viruses, Volume 11, Issue 6 (June 2019) – 96 articles
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Cover Story (view full-size image) Hepatitis C Virus (HCV) replicates in hepatocytes and often causes liver cirrhosis and [...] Read more. Hepatitis C Virus (HCV) replicates in hepatocytes and often causes liver cirrhosis and hepatocellular carcinoma. HCV establishes replication of its RNA genome in the cytoplasm. In the battle between the virus and cellular countermeasures, HCV induces expression of an as yet largely uncharacterized long-noncoding RNA (lncRNA), Lnc-ITM2C-1. This lncRNA in turn activates its neighboring gene coding for G protein-coupled receptor 55 (GPR55), a cannabinoid receptor, to suppress the induction of interferon-stimulated genes during the cellular innate immune response. View this paper.