Next Article in Journal
Hypsugopoxvirus: A Novel Poxvirus Isolated from Hypsugo savii in Italy
Next Article in Special Issue
Expanding the Diversity of Myoviridae Phages Infecting Lactobacillus plantarum—A Novel Lineage of Lactobacillus Phages Comprising Five New Members
Previous Article in Journal
Systematic Review of PCR Proof of Parvovirus B19 Genomes in Endomyocardial Biopsies of Patients Presenting with Myocarditis or Dilated Cardiomyopathy
Previous Article in Special Issue
Inactivation of Dairy Bacteriophages by Thermal and Chemical Treatments
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview

Understanding and Exploiting Phage–Host Interactions

1
Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Cork, Ireland
2
Institute for Global Food Security, School of Biological Sciences, Queen’s University, Belfast, 19 Chlorine Gardens, BT9 5DL Belfast, UK
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(6), 567; https://doi.org/10.3390/v11060567
Received: 29 March 2019 / Revised: 7 June 2019 / Accepted: 10 June 2019 / Published: 18 June 2019
  |  
PDF [2194 KB, uploaded 18 June 2019]
  |  

Abstract

Initially described a century ago by William Twort and Felix d’Herelle, bacteriophages are bacterial viruses found ubiquitously in nature, located wherever their host cells are present. Translated literally, bacteriophage (phage) means ‘bacteria eater’. Phages interact and infect specific bacteria while not affecting other bacteria or cell lines of other organisms. Due to the specificity of these phage–host interactions, the relationship between phages and their host cells has been the topic of much research. The advances in phage biology research have led to the exploitation of these phage–host interactions and the application of phages in the agricultural and food industry. Phages may provide an alternative to the use of antibiotics, as it is well known that the emergence of antibiotic-resistant bacterial infections has become an epidemic in clinical settings. In agriculture, pre-harvest and/or post-harvest application of phages to crops may prevent the colonisation of bacteria that are detrimental to plant or human health. In addition, the abundance of data generated from genome sequencing has allowed the development of phage-derived bacterial detection systems of foodborne pathogens. This review aims to outline the specific interactions between phages and their host and how these interactions may be exploited and applied in the food industry. View Full-Text
Keywords: bacteriophage; detection; biosensor; food-safety; agriculture; receptor binding protein; endolysin; phage–host interactions bacteriophage; detection; biosensor; food-safety; agriculture; receptor binding protein; endolysin; phage–host interactions
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Stone, E.; Campbell, K.; Grant, I.; McAuliffe, O. Understanding and Exploiting Phage–Host Interactions. Viruses 2019, 11, 567.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top