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Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt

National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, Egypt
General Organization for Veterinary Services, Nadi El-Said Street P.O. Box, 12619 Dokki, Cairo, Dokki-Giza, Egypt
Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, P.O. Box 582, 75123 Uppsala, Sweden
Author to whom correspondence should be addressed.
Viruses 2019, 11(6), 565;
Received: 30 May 2019 / Revised: 13 June 2019 / Accepted: 14 June 2019 / Published: 18 June 2019
(This article belongs to the Section Animal Viruses)
PDF [4272 KB, uploaded 18 June 2019]


Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus. View Full-Text
Keywords: Avian influenza; H5N2; H5N8; H9N2; reassortment; poultry; Egypt Avian influenza; H5N2; H5N8; H9N2; reassortment; poultry; Egypt

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Hagag, N.M.; Erfan, A.M.; El-Husseiny, M.; Shalaby, A.G.; Saif, M.A.; Tawakol, M.M.; Nour, A.A.; Selim, A.A.; Arafa, A.-S.; Hassan, M.K.; Hassan, W.M.M.; Fahmy, H.A.; Ibraheem, E.; Attia, M.; Abdelhakim, A.M.M.; Shahein, M.A.; Naguib, M.M. Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt. Viruses 2019, 11, 565.

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