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Open AccessArticle

Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso

Laboratoire de virologie, Centre national de référence du virus de l’hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, France
Centre MURAZ, Bobo-Dioulasso, Burkina Faso
Université Catholique d’Afrique de l’Ouest, Bobo-Dioulasso, Burkina Faso
Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso
Université Ouaga I Pr Joseph KI-ZERBO, Ouagadougou, Burkina Faso
Ministère de la Santé, Ouagadougou, Burkina Faso
Agence nationale de biosécurité, Ouagadougou, Burkina Faso
Pathogenesis and Control of Chronic Infections., Etablissement Français du Sang, CHU Montpellier, INSERM, University of Montpellier, 34090 Montpellier, France
Centre de Physiopathologie de Toulouse Purpan (CPTP), UMR Inserm, U1043, UMR CNRS, U5282, 31300 Toulouse, France
Author to whom correspondence should be addressed.
Viruses 2019, 11(6), 554;
Received: 17 May 2019 / Revised: 6 June 2019 / Accepted: 12 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Hepatitis E Virus)
Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country. View Full-Text
Keywords: Burkina Faso; hepatitis E virus; epidemiology; risk factors Burkina Faso; hepatitis E virus; epidemiology; risk factors
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Dimeglio, C.; Kania, D.; Mantono, J.M.; Kagoné, T.; Zida, S.; Tassembedo, S.; Dicko, A.; Tinto, B.; Yaro, S.; Hien, H.; Rouamba, J.; Bicaba, B.; Medah, I.; Meda, N.; Traoré, O.; Tuaillon, E.; Abravanel, F.; Izopet, J. Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso. Viruses 2019, 11, 554.

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