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Systematic Review of PCR Proof of Parvovirus B19 Genomes in Endomyocardial Biopsies of Patients Presenting with Myocarditis or Dilated Cardiomyopathy

1
Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle-Wittenberg, Mid-German Heart Center, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06120 Halle (Saale), Germany
2
Department of Anesthesiology, Helios Hospital Herzberg/Osterode, Dr.-Frössel-Allee, D-37412 Herzberg am Harz, Germany
3
School of Health Sciences, Faculty of Medicine, Department of Immunology & Histocompatibility, University of Thessaly, 41500 Larissa, Greece
4
Onassis Cardiac Surgery Center, Department of Cardiology, and National Kapodistrian University of Athens, Leoforou Andrea Siggrou 356, Kallithea, 17674 Athens, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(6), 566; https://doi.org/10.3390/v11060566
Received: 27 May 2019 / Revised: 11 June 2019 / Accepted: 12 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue New Insights into Parvovirus Research)
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Abstract

Background: Diverse viral infections have been associated with myocarditis (MC) and dilated cardiomyopathy (DCM). In this meta-analysis, we summarize the published results on the association of parvovirus B19 (B19V) genomes with human MC/DCM versus controls. Methods: n = 197 publications referring to B19V and MC or DCM were retrieved using multiple PubMed search modes. Out of these, n = 29 publications met the inclusion criteria with data from prospective analyses on >10 unselected patients presenting with MC or DCM (dataset: MA01). Data retrieved simultaneously from both controls and MC/DCM patients were available from n = 8 from these publications (dataset: MA02). Results: In the dataset MA01 B19V genomes were detected in 42.6% of the endomyocardial biopsies (EMB) in this cohort by PCR. In the dataset MA02 comprising n = 638 subjects, there was no statistically significant different rate of B19V positivity in myocardial tissues comparing controls (mean: 38.8 + 24.1%) versus the MC/DCM-patients (45.5 + 24.3%; p = 0.58). There was also no statistical difference between the positivity rate of B19V genomes in myocardial tissues of MA01 (46.0 + 19.5%) and the two patient groups of MA02 (p > 0.05). Conclusions: This systematic review reveals that the mean rate of PCR detected B19V genomes in patients presenting with MC/DCM does not differ significantly from the findings in control myocardial tissues. These data imply pathogenetically insignificant latency of B19V genomes in a proportion of myocardial tissues, both in MC-/DCM-patients and in controls. More information (i.e., replicative status, viral protein expression) is pertinent to achieve a comprehensive workup of myocardial B19V infection. View Full-Text
Keywords: parvovirus B19; B19V; erythrovirus; diagnosis; dilated cardiomyopathy; inflammatory cardiomyopathy; myocarditis; prognosis parvovirus B19; B19V; erythrovirus; diagnosis; dilated cardiomyopathy; inflammatory cardiomyopathy; myocarditis; prognosis
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Rigopoulos, A.G.; Klutt, B.; Matiakis, M.; Apostolou, A.; Mavrogeni, S.; Noutsias, M. Systematic Review of PCR Proof of Parvovirus B19 Genomes in Endomyocardial Biopsies of Patients Presenting with Myocarditis or Dilated Cardiomyopathy. Viruses 2019, 11, 566.

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