Special Issue "IFN-Independent ISG Expression and Its Role in Antiviral Cell-Intrinsic Innate Immunity"
Deadline for manuscript submissions: 15 April 2019
Dr. Takeshi Saito
Over the last few decades, accumulating evidence has demonstrated that many Interferon (IFN) stimulate genes (ISGs) can be directly upregulated by viruses independent of IFN signaling, and they have been called virus stimulated genes (VSGs). Indeed, whereas typical ISGs are driven by JAK-STAT signaling, VSG are upregulated through the IRF3 and NF-κB pathways. IFNs themselves are VSGs. Interestingly, VSGs have natural anticancer activities, and they may cause diseases in humans when induced chronically. To understand their role in host defense and pathogenesis, excellent model systems have been developed. However, there are still important gaps in our understanding of VSGs and host defense. Recently, RNA sequencing techniques have allowed the discovery of novel VSGs that also include non-coding RNAs. This Special Issue of Viruses will explore the impact of VSGs on the outcome of virus infection and of the role of these genes within the infected cells and organism. We will also focus on the most recent discoveries in VSG research, including the molecular biology of related virus–host interactions. Topics may include studies on various steps of gene induction, virus adaptation to VSGs, innate immune responses to virus infection, and mechanisms of virus immune evasion of related host defense pathways. The clinical presentation of VSG-driven pathology and strategies to use VSGs to cure chronic viral infections will also be a focus. In this Special Issue, we hope to assemble a collection of research papers and reviews that together will offer a comprehensive view on VSGs. Topics can include any aspects of VSGs and related biology; however, priority will be given to publications that utilize primary or iPSC derived-cells and/or patient samples/mouse models to validate data from in vitro studies. All submitted reviews should describe the precise regulation of the ISG/VSG that the authors have decided to write about.
Dr. Emmanuel Thomas
Dr. Takeshi Saito
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ISGs host defense
- VSGs and viral adaptation/evolution
- VSGs and therapeutics
- ISG antivirals
- molecular biology of host defense
- virus-host cell interactions
- antivirals targeting VSGs
- ISG pathogenesis and animal models