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Special Issue "Chikungunya Virus and (Re-) Emerging Alphaviruses"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 28 February 2019

Special Issue Editors

Guest Editor
Dr. Penghua Wang

Department of Immunology, Schoolf of Medicine, the University of Connecticut Health Center, Farmington, CT, United States
Website | E-Mail
Interests: innate immunity; pathogenesis; flaviviruses; alphaviruses; immune evasion; mouse model
Guest Editor
Dr. Rong Zhang

Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States
Website | E-Mail
Interests: arboviruses; alphaviruses; flaviruses; genetic screens; virus–host interactions

Special Issue Information

Dear Colleagues,

Since 2003, the “Old World” chikungunya virus has re-emerged and spread throughout the world in more than 40 countries, posing a big threat to public health. This mosquito-borne virus, belonging to the genus of Alphavirus in the family of Togaviridae, causes acute infection with symptoms ranging from fever, rash, myalgia, to severe arthralgia and arthritis. Although with a low fatality rate, this virus can produce chronic infection, characterized by muscle and joint pain which afflicts patients for months to years and has a substantial impact on their quality of life. Additionally, the (re-) emergence of other members of the genus Alphavirus that cause severe diseases in animals and/or humans has raised great concerns. Therefore, an overview of alphavirus research is timely and will greatly help the control and prevention of viral disease transmission.

In this Special Issue, we welcome the alphavirus community to submit research articles or review papers related to all aspects of chikungunya virus and other (re-) emerging alphaviruses, from virus discovery, phylogenetic and epidemiological studies, clinical diagnostics to basic research including, but not limited to, virus entry, cross-species transmission, replication and gene expression, viral immunity, and pathogenesis. Studies on the development of novel detection strategies, neutralizing antibodies, vaccines, and antiviral therapeutics are welcome.

Dr. Penghua Wang
Dr. Rong Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chikungunya virus
  • alphavirus
  • virus entry
  • viral immunity
  • pathogenesis
  • replication and gene expression
  • epidemiology
  • vaccine
  • neutralizing antibody
  • therapeutics

Published Papers (1 paper)

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Open AccessArticle Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti
Viruses 2018, 10(10), 571; https://doi.org/10.3390/v10100571
Received: 21 September 2018 / Revised: 15 October 2018 / Accepted: 16 October 2018 / Published: 18 October 2018
PDF Full-text (5235 KB) | HTML Full-text | XML Full-text | Supplementary Files
The transmission cycle of chikungunya virus (CHIKV) requires that mosquito vectors get persistently infected with the virus, following its oral acqsuisition from a vertebrate host. The mosquito midgut is the initial organ that gets infected with orally acquired CHIKV. Following its replication in
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The transmission cycle of chikungunya virus (CHIKV) requires that mosquito vectors get persistently infected with the virus, following its oral acqsuisition from a vertebrate host. The mosquito midgut is the initial organ that gets infected with orally acquired CHIKV. Following its replication in the midgut epithelium, the virus exits the midgut and infects secondary tissues including the salivary glands before being transmitted to another host. Here, we investigate the pattern of CHIKV dissemination from the midgut of Aedes aegypti at the ultrastructural level. Bloodmeal ingestion caused overstretching of the midgut basal lamina (BL), which was disrupted in areas adjacent to muscles surrounding the midgut as shown by scanning electron microscopy (SEM). Using both transmission electron microscopy (TEM) and focused ion beam scanning electron microscopy (FIB-SEM) to analyze midgut preparations, mature chikungunya (CHIK) virions were found accumulating at the BL and within strands of the BL at 24–32 h post-infectious bloodmeal (pibm). From 48 h pibm onwards, virions no longer congregated at the BL and became dispersed throughout the basal labyrinth of the epithelial cells. Ingestion of a subsequent, non-infectious bloodmeal caused mature virions to congregate again at the midgut BL. Our study suggests that CHIKV needs a single replication cycle in the midgut epithelium before mature virions directly traverse the midgut BL during a relatively narrow time window, within 48 h pibm. Full article
(This article belongs to the Special Issue Chikungunya Virus and (Re-) Emerging Alphaviruses)

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