Table of Contents
Viruses, Volume 11, Issue 2 (February 2019) – 107 articles
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Cover Story (view full-size image) Many enveloped viruses employ late domains such as PPXY to recruit the host ESCRT machinery needed [...] Read more. Many enveloped viruses employ late domains such as PPXY to recruit the host ESCRT machinery needed for budding and particle release. Paramyxoviruses typically lack late domain sequences, yet budding of these viruses is often ESCRT-dependent. Here, we provide evidence for a model in which paramyxoviruses use AMOTL1 as a linker to indirectly recruit the same WW domain-containing NEDD4 ubiquitin ligases for budding that other enveloped viruses recruit directly through PPXY late domains. View this paper.