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Complexities of Type I Interferon Biology: Lessons from LCMV

School of Life and Environmental Sciences, the Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, and the Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia
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Viruses 2019, 11(2), 172; https://doi.org/10.3390/v11020172
Received: 22 January 2019 / Revised: 17 February 2019 / Accepted: 18 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue LCMV – A Pillar for Immunology Research)
Over the past decades, infection of mice with lymphocytic choriomeningitis virus (LCMV) has provided an invaluable insight into our understanding of immune responses to viruses. In particular, this model has clarified the central roles that type I interferons play in initiating and regulating host responses. The use of different strains of LCMV and routes of infection has allowed us to understand how type I interferons are critical in controlling virus replication and fostering effective antiviral immunity, but also how they promote virus persistence and functional exhaustion of the immune response. Accordingly, these discoveries have formed the foundation for the development of novel treatments for acute and chronic viral infections and even extend into the management of malignant tumors. Here we review the fundamental insights into type I interferon biology gained using LCMV as a model and how the diversity of LCMV strains, dose, and route of administration have been used to dissect the molecular mechanisms underpinning acute versus persistent infection. We also identify gaps in the knowledge regarding LCMV regulation of antiviral immunity. Due to its unique properties, LCMV will continue to remain a vital part of the immunologists’ toolbox. View Full-Text
Keywords: lymphocytic choriomeningitis virus; type I interferon; innate immune response; adaptive immune response; CD8+ T cells; pathogen recognition; chronic infection; acute infection lymphocytic choriomeningitis virus; type I interferon; innate immune response; adaptive immune response; CD8+ T cells; pathogen recognition; chronic infection; acute infection
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MDPI and ACS Style

Suprunenko, T.; Hofer, M.J. Complexities of Type I Interferon Biology: Lessons from LCMV. Viruses 2019, 11, 172. https://doi.org/10.3390/v11020172

AMA Style

Suprunenko T, Hofer MJ. Complexities of Type I Interferon Biology: Lessons from LCMV. Viruses. 2019; 11(2):172. https://doi.org/10.3390/v11020172

Chicago/Turabian Style

Suprunenko, Tamara, and Markus J. Hofer 2019. "Complexities of Type I Interferon Biology: Lessons from LCMV" Viruses 11, no. 2: 172. https://doi.org/10.3390/v11020172

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