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Viruses, Volume 17, Issue 9

September 2025 - 136 articles

Cover Story: Multipartite viruses achieve infection only through the precise interplay of their genome segments, a feature that has long challenged the development of experimental models. In this study, we report the construction of full-length tandem-dimer infectious clones for all eight genomic components of Milk Vetch Dwarf Virus (MDV). Agroinoculation of these clones successfully reconstituted systemic infections in Nicotiana benthamiana, Vicia faba, Vigna unguiculata and N. tabacum. Molecular assays confirmed the coordinated presence of viral segments, while host-dependent differences in their accumulation were revealed. This infectious clone system represents the first complete framework for MDV, providing a powerful platform to explore replication, host adaptation, and segment cooperation in nanoviruses. View this paper
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Articles (136)

  • Article
  • Open Access
1,573 Views
19 Pages

Genome-Wide Variation Profile of the Genus Tobamovirus

  • Amany E. Gomaa and
  • Hernan Garcia-Ruiz

22 September 2025

The genus Tobamovirus belongs to the family Virgaviridae, and the genome consists of monopartite, positive, single-strand RNA. Most species contain four open reading frames encoding four essential proteins. Transmission occurs primarily through mecha...

  • Brief Report
  • Open Access
726 Views
10 Pages

22 September 2025

Depot medroxyprogesterone acetate (Depo-Provera) has been associated with an increased risk of HIV acquisition. We have previously shown that Depo-Provera administration increases immune markers for HIV preference on peripheral and cervical CD4+ T ce...

  • Article
  • Open Access
834 Views
17 Pages

22 September 2025

Feline coronaviruses (FCoVs) are divided into two groups: feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). FIPV is responsible for the severe disease known as feline infectious peritonitis, while FECV typically causes...

  • Correction
  • Open Access
393 Views
1 Page

Correction: Galuzo et al. CLEC5A Activation in Inflammatory Monocytes: A Mechanism for Enhanced Adaptive Immunity Following COVID-19 mRNA Vaccination in a Preclinical Study. Viruses 2025, 17, 1233

  • Renan Galuzo,
  • Thiago Lazari Machado,
  • Ryann de Souza Nascimento,
  • Jorvan Ramos de Medeiros,
  • Luciana Neves Tubarão,
  • Jane Silva,
  • Vanessa Pimenta Rocha,
  • Tamiris Azamor,
  • Felipe Soares Coelho and
  • Andrea Marques Vieira da Silva
  • + 8 authors

22 September 2025

In the original publication [...]

  • Article
  • Open Access
1,518 Views
16 Pages

Ruvidar®—An Effective Anti-Herpes Simplex Virus Agent

  • Kevin M. Coombs,
  • Roger DuMoulin-White and
  • Arkady Mandel

20 September 2025

Infectious agents account for millions of deaths every year. The Herpes Simplex Viruses (HSVs) are large double-stranded DNA viruses that infect more than 90% of the human population and can establish life-long latency in human hosts. Currently, effe...

  • Article
  • Open Access
659 Views
17 Pages

Structural Insights into the Nuclear Import of Haliotid Herpesvirus 1 Large Tegument Protein Homologue

  • Babu Kanti Nath,
  • Crystall M. D. Swarbrick,
  • Renate H. M. Schwab,
  • Daryl Ariawan,
  • Ole Tietz,
  • Jade K. Forwood and
  • Subir Sarker

20 September 2025

Abalone are highly susceptible to haliotid herpesvirus 1 (HaHV1), the causative agent of abalone viral ganglioneuritis (AVG), a re-emerging disease responsible for significant mortality events in both wild and farmed populations. Currently, there are...

  • Article
  • Open Access
847 Views
15 Pages

RNA Polymerase III Regulates HIV Replication and Latency

  • Landon Thompson,
  • Imran Jamal,
  • Juthika Das,
  • Casey Dang,
  • Zhenzi Hong,
  • Doran Katz,
  • Alberto Bosque and
  • Vir B. Singh

20 September 2025

The elimination of HIV latent reservoirs is an extremely challenging task due to the interplay of multiple mechanisms regulating latency. Thus, we need to identify novel strategies to target heterogeneous reservoirs uniformly. Recent reports have pro...

  • Article
  • Open Access
715 Views
29 Pages

20 September 2025

Type I interferons (IFNs), mainly IFN-α and IFN-β, play an essential role in defending against viral invasion by inducing the host’s innate antiviral response. Porcine reproductive and respiratory syndrome virus (PRRSV) is known to i...

  • Article
  • Open Access
593 Views
25 Pages

Living Together Apart: Quantitative Perspectives on the Costs and Benefits of a Multipartite Genome Organization in Viruses

  • Marcelle L. Johnson,
  • Dieke Boezen,
  • Alexey A. Grum-Grzhimaylo,
  • René A. A. van der Vlugt,
  • J. Arjan G. M. de Visser and
  • Mark P. Zwart

20 September 2025

Background: Multipartite viruses individually package their multiple genome segments into virus particles, necessitating the transmission of multiple virus particles for effective viral spread. This dependence poses a cost in the form of reduced tran...

  • Review
  • Open Access
2,065 Views
28 Pages

Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision Therapeutics

  • Mustafa Ozdogan,
  • Gizem Tutkun,
  • Muharrem Okan Cakir and
  • Gholam Hossein Ashrafi

20 September 2025

Human papillomavirus (HPV) plays a major role in the development of head and neck cancers (HNCs), particularly oropharyngeal squamous cell carcinoma. This review highlights the key molecular mechanisms of HPV-driven carcinogenesis, focusing on the on...

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Viruses - ISSN 1999-4915