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Marine Drugs, Volume 17, Issue 5

May 2019 - 64 articles

Cover Story: Over the last decade, genomes and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess unique metabolic pathways and can potentially produce specific secondary metabolites with biological activity. Because microalgae are very diverse and adapted to different environmental conditions, the chances to find novel bioactives with biotechnological applications are high. Exploration and exploitation of available –omics datasets, and the current trend to generate new ones will increase the opportunities to identify new target species, new bioactivities and new marine natural products from microalgae. View this paper.
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Articles (64)

  • Article
  • Open Access
78 Citations
9,143 Views
15 Pages

Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin

  • Song Yi Koo,
  • Ji-Hyun Hwang,
  • Seung-Hoon Yang,
  • Jae-In Um,
  • Kwang Won Hong,
  • Kyungsu Kang,
  • Cheol-Ho Pan,
  • Keum Taek Hwang and
  • Sang Min Kim

27 May 2019

Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially beca...

  • Article
  • Open Access
12 Citations
4,665 Views
10 Pages

25 May 2019

The replacement of synthetic compounds by natural products witnesses an increasing demand from the pharmaceutical, cosmetic, food and nutraceutical industries. Included in the set of natural raw materials that are poorly explored are the macroalgae....

  • Article
  • Open Access
23 Citations
5,549 Views
12 Pages

24 May 2019

Actinomycin V, an analog of actinomycin D produced by the marine-derived actinomycete Streptomyces sp., possessing a 4-ketoproline instead of a 4-proline in actinomycin D. In this study, the involvement of snail/slug-mediated epithelial-mesenchymal t...

  • Review
  • Open Access
553 Citations
25,047 Views
29 Pages

Microalgae for High-Value Products Towards Human Health and Nutrition

  • Ines Barkia,
  • Nazamid Saari and
  • Schonna R. Manning

24 May 2019

Microalgae represent a potential source of renewable nutrition and there is growing interest in algae-based dietary supplements in the form of whole biomass, e.g., Chlorella and Arthrospira, or purified extracts containing omega-3 fatty acids and car...

  • Feature Paper
  • Article
  • Open Access
12 Citations
4,145 Views
17 Pages

Synthetic Pinnatoxins A and G Reversibly Block Mouse Skeletal Neuromuscular Transmission In Vivo and In Vitro

  • Evelyne Benoit,
  • Aurélie Couesnon,
  • Jiri Lindovsky,
  • Bogdan I. Iorga,
  • Rómulo Aráoz,
  • Denis Servent,
  • Armen Zakarian and
  • Jordi Molgó

24 May 2019

Pinnatoxins (PnTXs) A-H constitute an emerging family belonging to the cyclic imine group of phycotoxins. Interest has been focused on these fast-acting and highly-potent toxins because they are widely found in contaminated shellfish. Despite their h...

  • Article
  • Open Access
36 Citations
6,374 Views
19 Pages

Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms

  • Said M. Daboor,
  • Renee Raudonis,
  • Alejandro Cohen,
  • John R. Rohde and
  • Zhenyu Cheng

24 May 2019

Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is...

  • Article
  • Open Access
55 Citations
5,578 Views
14 Pages

Characterization of an Alkaline Alginate Lyase with pH-Stable and Thermo-Tolerance Property

  • Yanan Wang,
  • Xuehong Chen,
  • Xiaolin Bi,
  • Yining Ren,
  • Qi Han,
  • Yu Zhou,
  • Yantao Han,
  • Ruyong Yao and
  • Shangyong Li

24 May 2019

Alginate oligosaccharides (AOS) show versatile bioactivities. Although various alginate lyases have been characterized, enzymes with special characteristics are still rare. In this study, a polysaccharide lyase family 7 (PL7) alginate lyase-encoding...

  • Article
  • Open Access
7 Citations
5,832 Views
13 Pages

24 May 2019

This study examined whether deep ocean mineral (DOM) supplementation improved high-intensity intermittent running capacity after short-term recovery from an initial bout of prolonged high-intensity running in thermoneutral environmental conditions. N...

  • Article
  • Open Access
8 Citations
3,900 Views
13 Pages

23 May 2019

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are involved in fast synaptic transmission and mediated physiological activities in the nervous system. α-Conotoxin ImI exhibits subtype-specific blockade towards hom...

  • Article
  • Open Access
27 Citations
4,576 Views
16 Pages

22 May 2019

Hizikia fusiformis (Harvey) Okamura is an edible marine alga that has been widely used in Korea, China, and Japan as a rich source of dietary fiber and essential minerals. In our previous study, we observed that the methanol extract of H. fusiformis...

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Mar. Drugs - ISSN 1660-3397