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Three New Isoflavonoid Glycosides from the Mangrove-Derived Actinomycete Micromonospora aurantiaca 110B

1
Ocean College, Zhejiang University, Zhoushan 316021, China
2
College of Biochemical Engineering, Anhui Polytechnic University, Wuhu 241000, China
3
Zhejiang Key Laboratory of Antifungal Drugs, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 294; https://doi.org/10.3390/md17050294
Received: 4 May 2019 / Accepted: 13 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Abstract

The mangrove ecosystem is a rich resource for the discovery of actinomycetes with potential applications in pharmaceutical science. Besides the genus Streptomyces, Micromonospora is also a source of new bioactive agents. We screened Micromonospora from the rhizosphere soil of mangrove plants in Fujian province, China, and 51 strains were obtained. Among them, the extracts of 12 isolates inhibited the growth of human lung carcinoma A549 cells. Strain 110B exhibited better cytotoxic activity, and its bioactive constituents were investigated. Consequently, three new isoflavonoid glycosides, daidzein-4′-(2-deoxy-α-l-fucopyranoside) (1), daidzein-7-(2-deoxy-α-l-fucopyranoside) (2), and daidzein-4′,7-di-(2-deoxy-α-l-fucopyranoside) (3) were isolated from the fermentation broth of strain 110B. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The result of medium-changing experiments implicated that these new compounds were microbial biotransformation products of strain M. aurantiaca 110B. The three compounds displayed moderate cytotoxic activity to the human lung carcinoma cell line A549, hepatocellular liver carcinoma cell line HepG2, and the human colon tumor cell line HCT116, whereas none of them showed antifungal or antibacterial activities. View Full-Text
Keywords: Micromonospora aurantiaca 110B; isoflavonoid glycosides; structure elucidation; cytotoxic activity Micromonospora aurantiaca 110B; isoflavonoid glycosides; structure elucidation; cytotoxic activity
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Wang, R.-J.; Zhang, S.-Y.; Ye, Y.-H.; Yu, Z.; Qi, H.; Zhang, H.; Xue, Z.-L.; Wang, J.-D.; Wu, M. Three New Isoflavonoid Glycosides from the Mangrove-Derived Actinomycete Micromonospora aurantiaca 110B. Mar. Drugs 2019, 17, 294.

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