Next Article in Journal
Zeaxanthin Isolated from Dunaliella salina Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors
Next Article in Special Issue
New Ophiobolin Derivatives from the Marine Fungus Aspergillus flocculosus and Their Cytotoxicities against Cancer Cells
Previous Article in Journal
Antihypertensive Effect in Vivo of QAGLSPVR and Its Transepithelial Transport Through the Caco-2 Cell Monolayer
Previous Article in Special Issue
Isolation, Identification of Carotenoid-Producing Rhodotorula sp. from Marine Environment and Optimization for Carotenoid Production
Article

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

1
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
2
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 289; https://doi.org/10.3390/md17050289
Received: 18 April 2019 / Revised: 4 May 2019 / Accepted: 8 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Marine Microbial Diversity as a Source of Bioactive Natural Products)
Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. View Full-Text
Keywords: marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins
Show Figures

Figure 1

MDPI and ACS Style

Xu, X.; Han, J.; Wang, Y.; Lin, R.; Yang, H.; Li, J.; Wei, S.; Polyak, S.W.; Song, F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Mar. Drugs 2019, 17, 289. https://doi.org/10.3390/md17050289

AMA Style

Xu X, Han J, Wang Y, Lin R, Yang H, Li J, Wei S, Polyak SW, Song F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Marine Drugs. 2019; 17(5):289. https://doi.org/10.3390/md17050289

Chicago/Turabian Style

Xu, Xiuli; Han, Jiahui; Wang, Yanan; Lin, Rui; Yang, Haijin; Li, Jiangpeng; Wei, Shangzhu; Polyak, Steven W.; Song, Fuhang. 2019. "Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049" Mar. Drugs 17, no. 5: 289. https://doi.org/10.3390/md17050289

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop