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Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 289;
Received: 18 April 2019 / Revised: 4 May 2019 / Accepted: 8 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Marine Microbial Diversity as Source of Bioactive Natural Products)
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Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. View Full-Text
Keywords: marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins

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Xu, X.; Han, J.; Wang, Y.; Lin, R.; Yang, H.; Li, J.; Wei, S.; Polyak, S.W.; Song, F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Mar. Drugs 2019, 17, 289.

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