Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

Xu, Xiuli; Han, Jiahui; Wang, Yanan; Lin, Rui; Yang, Haijin; Li, Jiangpeng; Wei, Shangzhu; Polyak, Steven W.; Song, Fuhang

doi:10.3390/md17050289

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

Printed Edition

A printed edition of this Special Issue is available at MDPI Books....

...

Open AccessArticle

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

^1,*,

^1,2,

¹,

¹,

¹,

¹,

¹,

and

^2,*

School of Ocean Sciences, China University of Geosciences, Beijing 100083, China

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia

Authors to whom correspondence should be addressed.

Mar. Drugs 2019, 17(5), 289; https://doi.org/10.3390/md17050289

Received: 18 April 2019 / Revised: 4 May 2019 / Accepted: 8 May 2019 / Published: 14 May 2019

(This article belongs to the Special Issue Marine Microbial Diversity as a Source of Bioactive Natural Products)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. View Full-Text

Keywords: marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary File 1:
PDF-Document (PDF, 1216 KiB)

Share and Cite

MDPI and ACS Style

Xu, X.; Han, J.; Wang, Y.; Lin, R.; Yang, H.; Li, J.; Wei, S.; Polyak, S.W.; Song, F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Mar. Drugs 2019, 17, 289. https://doi.org/10.3390/md17050289

AMA Style

Xu X, Han J, Wang Y, Lin R, Yang H, Li J, Wei S, Polyak SW, Song F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Marine Drugs. 2019; 17(5):289. https://doi.org/10.3390/md17050289

Chicago/Turabian Style

Xu, Xiuli, Jiahui Han, Yanan Wang, Rui Lin, Haijin Yang, Jiangpeng Li, Shangzhu Wei, Steven W. Polyak, and Fuhang Song. 2019. "Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049" Marine Drugs 17, no. 5: 289. https://doi.org/10.3390/md17050289

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Printed Edition

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI