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Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

1
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
2
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 289; https://doi.org/10.3390/md17050289
Received: 18 April 2019 / Revised: 4 May 2019 / Accepted: 8 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Marine Microbial Diversity as Source of Bioactive Natural Products)
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Abstract

Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. View Full-Text
Keywords: marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins
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Xu, X.; Han, J.; Wang, Y.; Lin, R.; Yang, H.; Li, J.; Wei, S.; Polyak, S.W.; Song, F. Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049. Mar. Drugs 2019, 17, 289.

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