Next Article in Journal
A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease
Previous Article in Journal
Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle

Novel Bioactive Penicipyrroether A and Pyrrospirone J from the Marine-Derived Penicillium sp. ZZ380

1
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 292; https://doi.org/10.3390/md17050292
Received: 9 April 2019 / Revised: 28 April 2019 / Accepted: 7 May 2019 / Published: 15 May 2019
  |  
PDF [3073 KB, uploaded 15 May 2019]
  |  

Abstract

The marine-sourced fungus Penicillium sp. ZZ380 was previously reported to have the ability to produce a series of new pyrrospirone alkaloids. Further investigation on this strain resulted in the isolation and identification of novel penicipyrroether A and pyrrospirone J. Each of them represents the first example of its structural type, with a unique 6/5/6/5 polycyclic fusion that is different from the 6/5/6/6 fused ring system for the reported pyrrospirones. Their structures were elucidated by extensive nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic analyses, electronic circular dichroism (ECD) and 13C NMR calculations and X-ray single crystal diffraction. Penicipyrroether A showed potent antiproliferative activity against human glioma U87MG and U251 cells with half maximal inhibitory concentration (IC50) values of 1.64–5.50 μM and antibacterial inhibitory activity with minimum inhibitory concentration (MIC) values of 1.7 μg/mL against methicillin-resistant Staphylococcus aureus and 3.0 μg/mL against Escherichia coli. View Full-Text
Keywords: marine fungus; Penicillium sp. ZZ380; penicipyrroether A; pyrrospirone J; antiproliferative and antibacterial activities marine fungus; Penicillium sp. ZZ380; penicipyrroether A; pyrrospirone J; antiproliferative and antibacterial activities
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Song, T.; Tang, M.; Ge, H.; Chen, M.; Lian, X.; Zhang, Z. Novel Bioactive Penicipyrroether A and Pyrrospirone J from the Marine-Derived Penicillium sp. ZZ380. Mar. Drugs 2019, 17, 292.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top