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Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides

Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China
University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 296;
Received: 8 April 2019 / Revised: 10 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Bioactive Marine Heterocyclic Compounds)
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Five new polyketides, namely, 5R-hydroxyrecifeiolide (1), 5S-hydroxyrecifeiolide (2), ent-cladospolide F (3), cladospolide G (4), and cladospolide H (5), along with two known compounds (6 and 7), were isolated from the endophytic fungal strain Cladosporium cladosporioides MA-299 that was obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, ECDs and optical rotations, and modified Mosher’s method. The structures of 3 and 6 were confirmed by single-crystal X-ray diffraction analysis and this is the first time for reporting the crystal structures of these two compounds. All of the isolated compounds were examined for antimicrobial activities against human and aquatic bacteria and plant pathogenic fungi as well as enzymatic inhibitory activities against acetylcholinesterase. Compounds 14, 6, and 7 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 1.0 to 64 μg/mL, while 3 exhibited enzymatic inhibitory activity against acetylcholinesterase with the IC50 value of 40.26 μM. View Full-Text
Keywords: mangrove plant; endophytic fungus; Cladosporium cladosporioides; polyketides; antimicrobial activity; acetylcholinesterase; enzymatic inhibitory activity mangrove plant; endophytic fungus; Cladosporium cladosporioides; polyketides; antimicrobial activity; acetylcholinesterase; enzymatic inhibitory activity

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Zhang, F.-Z.; Li, X.-M.; Li, X.; Yang, S.-Q.; Meng, L.-H.; Wang, B.-G. Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides. Mar. Drugs 2019, 17, 296.

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