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Oceans as a Source of Immunotherapy

Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea
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Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 282; https://doi.org/10.3390/md17050282
Received: 30 March 2019 / Revised: 3 May 2019 / Accepted: 6 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Marine Immunomodulators)
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Abstract

Marine flora is taxonomically diverse, biologically active, and chemically unique. It is an excellent resource, which offers great opportunities for the discovery of new biopharmaceuticals such as immunomodulators and drugs targeting cancerous, inflammatory, microbial, and fungal diseases. The ability of some marine molecules to mediate specific inhibitory activities has been demonstrated in a range of cellular processes, including apoptosis, angiogenesis, and cell migration and adhesion. Immunomodulators have been shown to have significant therapeutic effects on immune-mediated diseases, but the search for safe and effective immunotherapies for other diseases such as sinusitis, atopic dermatitis, rheumatoid arthritis, asthma and allergies is ongoing. This review focuses on the marine-originated bioactive molecules with immunomodulatory potential, with a particular focus on the molecular mechanisms of specific agents with respect to their targets. It also addresses the commercial utilization of these compounds for possible drug improvement using metabolic engineering and genomics. View Full-Text
Keywords: immunotherapy; inflammation; marine drug; marine flora; Toll-like receptor immunotherapy; inflammation; marine drug; marine flora; Toll-like receptor
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Ahmad, B.; Shah, M.; Choi, S. Oceans as a Source of Immunotherapy. Mar. Drugs 2019, 17, 282.

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