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Open AccessArticle

Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin

1
Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea
2
Smart Farm Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea
3
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Korea
4
R&D Department, AlgaeTech Co. Ltd., Gangneung 25457, Korea
5
Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea
6
Division of Bio-Medical Science & Technology, University of Science & Technology, Daejeon 34113, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 311; https://doi.org/10.3390/md17050311
Received: 10 April 2019 / Revised: 23 May 2019 / Accepted: 24 May 2019 / Published: 27 May 2019
(This article belongs to the Collection Marine Carotenoids)
Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor γ (PPARγ) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight. View Full-Text
Keywords: anti-obesity effect; Phaeodactylum tricornutum; fucoxanthin; Phaeodactylum extract; microalgae anti-obesity effect; Phaeodactylum tricornutum; fucoxanthin; Phaeodactylum extract; microalgae
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MDPI and ACS Style

Koo, S.Y.; Hwang, J.-H.; Yang, S.-H.; Um, J.-I.; Hong, K.W.; Kang, K.; Pan, C.-H.; Hwang, K.T.; Kim, S.M. Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin. Mar. Drugs 2019, 17, 311.

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