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Marine Drugs, Volume 17, Issue 2

February 2019 - 64 articles

Cover Story: Marine sponges of the genus Suberea (family Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. This article presents a comprehensive literature survey covering the period of 1998–2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of different skeletons of halogenated compounds. View this paper.
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Articles (64)

  • Article
  • Open Access
81 Citations
6,933 Views
11 Pages

21 February 2019

β-thymosin is known for having 43 amino acids, being water-soluble, having a light molecular weight and ubiquitous polypeptide. The biological activities of β-thymosin are diverse and include the promotion of wound healing, reduction of inf...

  • Article
  • Open Access
79 Citations
8,058 Views
16 Pages

20 February 2019

Microalgae of the genus Porphyridium show great potential for large-scale commercial cultivation, as they accumulate large quantities of B-phycoerythrin (B-PE), long chain polyunsaturated fatty acids (LC-PUFAs) and exopolysaccharide (EPS). The presen...

  • Article
  • Open Access
20 Citations
5,208 Views
12 Pages

Fusarisolins A–E, Polyketides from the Marine-Derived Fungus Fusarium solani H918

  • Siwen Niu,
  • Xi-Xiang Tang,
  • Zuowang Fan,
  • Jin-Mei Xia,
  • Chun-Lan Xie and
  • Xian-Wen Yang

20 February 2019

Five new (fusarisolins A–E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusarium solani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscop...

  • Article
  • Open Access
43 Citations
5,350 Views
15 Pages

9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells

  • Qingmei Sun,
  • Fufeng Liu,
  • Jingcheng Sang,
  • Miaoman Lin,
  • Jiale Ma,
  • Xiao Xiao,
  • Sicheng Yan,
  • C. Benjamin Naman,
  • Ning Wang and
  • Shan He
  • + 3 authors

18 February 2019

β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer’s disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, and produce neurotoxicity. Therefore, Aβ ag...

  • Article
  • Open Access
24 Citations
5,116 Views
13 Pages

Anti-Proliferation Activity of a Decapeptide from Perinereies aibuhitensis toward Human Lung Cancer H1299 Cells

  • Shuoqi Jiang,
  • Yinglu Jia,
  • Yunping Tang,
  • Die Zheng,
  • Xingbiao Han,
  • Fangmiao Yu,
  • Yan Chen,
  • Fangfang Huang,
  • Zuisu Yang and
  • Guofang Ding

18 February 2019

Perinereis aibuhitensis peptide (PAP) is a decapeptide (Ile-Glu-Pro-Gly-Thr-Val-Gly-Met-Met-Phe, IEPGTVGMMF) with anticancer activity that was purified from an enzymatic hydrolysate of Perinereis aibuhitensis. In the present study, the anticancer eff...

  • Article
  • Open Access
61 Citations
6,991 Views
18 Pages

18 February 2019

Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer’s disease (A...

  • Article
  • Open Access
7 Citations
4,148 Views
10 Pages

Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum

  • Yang Cheng,
  • Atallah F. Ahmed,
  • Raha S. Orfali,
  • Chang-Feng Dai and
  • Jyh-Horng Sheu

17 February 2019

Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (1‒3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses...

  • Article
  • Open Access
70 Citations
5,015 Views
17 Pages

15 February 2019

Polyunsaturated fatty acids (PUFAs) are essential for human function, however they have to be provided through the diet. As their production from fish oil is environmentally unsustainable, there is demand for new sources of PUFAs. The aim of the pres...

  • Communication
  • Open Access
5 Citations
4,181 Views
8 Pages

14 February 2019

Fucosylated oligosaccharide (FO) is known to selectively promote the growth of probiotic bacteria and is currently marketed as a functional health food and prebiotic in infant formula. Despite widespread interest in FO among functional food customers...

  • Review
  • Open Access
97 Citations
13,659 Views
12 Pages

14 February 2019

The extraction and purification of collagen are of great interest due to its biological function and medicinal applications. Although marine invertebrates are abundant in the animal kingdom, our knowledge of their extracellular matrix (ECM), which ma...

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Mar. Drugs - ISSN 1660-3397