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Special Issue "Marine-Derived Polyketides with Antibiotic Activity"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 May 2019)

Special Issue Editor

Guest Editor
Prof. Dr. Till F. Schäberle

Head of Natural Product Research, Institute for Insect Biotechnology, University of Giessen, Giessen, Germany
Website | E-Mail
Interests: natural products isolation and characterization; bioassay-guided purification of natural products/drug discovery; isolation of natural product producing bacteria; bioinformatics; analysis of biosynthetic gene clusters; metagenomics

Special Issue Information

Dear Colleagues,

Polyketides are a class of specialized metabolites produced by a wide variety of organisms. Most intriguing is the fact that these compounds show a multitude of biological activities, e.g., antibacterial activities. They are in the focus of research from an ecological, as well as pharmaceutical point of view, since many medicinal drugs are natural polyketides per se, or are based on them. Hence, polyketides possess the potential to become leads for novel medicinal drugs. Especially in the antibiotics field exists a pressing need to identify and evaluate novel structures. The current drugs, contributing to the increased life expectancy of humans, are losing their power due to antimicrobial resistance development and dispersion.

The goal of this Marine Drugs Special Issue is to assemble a collection of scientific articles outlining the diversity, the biosynthesis and the antibiotic potential of marine-derived polyketides.

Scientists from various fields are invited to contribute, to combine interdisciplinary expertise in marine-derived polyketides research, e.g., (micro)biology, analytical chemistry, bioinformatics, pharmacy, and biotechnology.

Prof. Dr. Till F. Schäberle
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polyketide
  • PKS
  • Mixed PKS/NRPS
  • natural product
  • secondary metabolite
  • specialized metabolite
  • biosynthesis
  • antibiotic
  • antibacterial

Published Papers (2 papers)

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Research

Open AccessArticle
Fusarisolins A–E, Polyketides from the Marine-Derived Fungus Fusarium solani H918
Mar. Drugs 2019, 17(2), 125; https://doi.org/10.3390/md17020125
Received: 31 January 2019 / Revised: 14 February 2019 / Accepted: 15 February 2019 / Published: 20 February 2019
Cited by 1 | PDF Full-text (2325 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Five new (fusarisolins A–E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusarium solani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscopic [...] Read more.
Five new (fusarisolins A–E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusarium solani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscopic data analyses, methoxyphenylacetic acid (MPA) method, chemical conversion, and by comparison with data reported in the literature. Compounds 1 and 2 are the first two naturally occurring 21 carbons polyketides featuring a rare β- and γ-lactone unit, respectively. All isolates (1 to 14) were evaluated for their inhibitory effects against tea pathogenic fungus Pestalotiopsis theae and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase gene expression. Compound 8 showed potent antifungal activity with an ED50 value of 55 μM, while 1, 8, 13, and 14 significantly inhibited HMG-CoA synthase gene expression. Full article
(This article belongs to the Special Issue Marine-Derived Polyketides with Antibiotic Activity)
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Open AccessArticle
Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity
Mar. Drugs 2018, 16(10), 369; https://doi.org/10.3390/md16100369
Received: 17 July 2018 / Revised: 1 October 2018 / Accepted: 3 October 2018 / Published: 8 October 2018
Cited by 1 | PDF Full-text (1747 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Bacteria of the family Rhodobacteraceae are widespread in marine environments and known to colonize surfaces, such as those of e.g., oysters and shells. The marine bacterium Labrenzia sp. 011 is here investigated and it was found to produce two cyclopropane-containing medium-chain fatty acids [...] Read more.
Bacteria of the family Rhodobacteraceae are widespread in marine environments and known to colonize surfaces, such as those of e.g., oysters and shells. The marine bacterium Labrenzia sp. 011 is here investigated and it was found to produce two cyclopropane-containing medium-chain fatty acids (1, 2), which inhibit the growth of a range of bacteria and fungi, most effectively that of a causative agent of Roseovarius oyster disease (ROD), Pseudoroseovarius crassostreae DSM 16950. Additionally, compound 2 acts as a potent partial, β-arrestin-biased agonist at the medium-chain fatty acid-activated orphan G-protein coupled receptor GPR84, which is highly expressed on immune cells. The genome of Labrenzia sp. 011 was sequenced and bioinformatically compared with those of other Labrenzia spp. This analysis revealed several cyclopropane fatty acid synthases (CFAS) conserved in all Labrenzia strains analyzed and a putative gene cluster encoding for two distinct CFASs is proposed as the biosynthetic origin of 1 and 2. Full article
(This article belongs to the Special Issue Marine-Derived Polyketides with Antibiotic Activity)
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