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Special Issue "Deep-Sea Natural Products II"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Dr. Olivier P. Thomas

Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
Website | E-Mail
Interests: marine natural products; marine toxins; harmful algal blooms; dinoflagellates; cyanobacteria; sponges; environmental metabolomics; marine chemical ecology

Special Issue Information

Dear Colleagues,

Until now, marine biodiscovery has been principally restricted to easily accessible marine areas. First, the intertidal environments of the oceans have been investigated and, with the development of SCUBA diving in the 1950s, access to the subtidal region to 50 to 60 m depth has been greatly facilitated. Recent years have witnessed several technological advances in (a) SCUBA diving with gas mixes; (b) the development of deep-submergence vehicles (DSV); or, more and more frequently today, (c) underwater remote operated vehicles (ROV). Today, all these techniques allow for the unveiling of fantastic marine biodiversity that was only described through trawling.

Associated with this largely unknown biodiversity, an untapped reservoir of biomolecules has to be uncovered. In this Special Issue, we aim to gather the most recent and promising findings in the structure elucidation of new metabolites isolated from deep-sea organisms, either macro- or micro-. Known metabolites isolated from the deep-sea but with new bioactivities will also be welcome, as well as side studies related to deep-sea natural products like those using dereplication and metabolomics approaches, or those focusing on the description of particular metabolic pathways.

Prof. Olivier P. Thomas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • bioactive compounds
  • structure elucidation
  • metabolites
  • deep-sea
  • extreme environments

Published Papers (3 papers)

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Research

Open AccessArticle
New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398
Mar. Drugs 2019, 17(5), 253; https://doi.org/10.3390/md17050253
Received: 2 April 2019 / Revised: 18 April 2019 / Accepted: 25 April 2019 / Published: 28 April 2019
PDF Full-text (1650 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A–C (13), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample [...] Read more.
Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A–C (13), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A–C (13) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (610) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines. Full article
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Figures

Graphical abstract

Open AccessArticle
Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host
Mar. Drugs 2019, 17(2), 127; https://doi.org/10.3390/md17020127
Received: 1 February 2019 / Revised: 15 February 2019 / Accepted: 17 February 2019 / Published: 21 February 2019
PDF Full-text (826 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Aborycin is a ribosomally synthesized member of the type I lasso peptide natural products. In the present study, aborycin was isolated and identified from the deep-sea-derived microbe Streptomyces sp. SCSIO ZS0098. The aborycin biosynthetic gene cluster (abo) was identified on the [...] Read more.
Aborycin is a ribosomally synthesized member of the type I lasso peptide natural products. In the present study, aborycin was isolated and identified from the deep-sea-derived microbe Streptomyces sp. SCSIO ZS0098. The aborycin biosynthetic gene cluster (abo) was identified on the basis of genome sequence analyses and then heterologously expressed in Streptomyces coelicolor M1152 to effectively produce aborycin. Aborycin generated in this fashion exhibited moderate antibacterial activity against 13 Staphylococcus aureus strains from various sources with minimum inhibitory concentrations MICs = 8.0~128 µg/mL, against Enterococcus faecalis ATCC 29212 with an MIC = 8.0 µg/mL, and against Bacillus thuringiensis with MIC = 2.0 µg/mL. Additionally, aborycin displayed potent antibacterial activity (MIC = 0.5 µg/mL) against the poultry pathogen Enterococcus gallinarum 5F52C. The reported abo cluster clearly has the potential to provide a means of expanding the repertoire of anti-infective type I lasso peptides. Full article
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Figures

Figure 1

Open AccessArticle
Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008
Mar. Drugs 2018, 16(11), 448; https://doi.org/10.3390/md16110448
Received: 11 October 2018 / Revised: 7 November 2018 / Accepted: 12 November 2018 / Published: 15 November 2018
Cited by 1 | PDF Full-text (3168 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Seven new unstable tetramic acid derivatives, cladosporiumins I-O (17), together with the known analogue cladodionen (8) were isolated from the extract of the deep-sea-derived fungus Cladosporium sphaerospermum EIODSF 008. Their structures were elucidated by spectroscopic analysis, quantum [...] Read more.
Seven new unstable tetramic acid derivatives, cladosporiumins I-O (17), together with the known analogue cladodionen (8) were isolated from the extract of the deep-sea-derived fungus Cladosporium sphaerospermum EIODSF 008. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations and ECD spectra. Compound 4 was a Mg complex of tetramic acid derivative. In acidic solvent, 4 could change to 1 and 6, and 7 could change to 5. In addition, 1, 5 and 8 existed as two exchangeable isomers, respectively. The structures of cladosporiumins E-H were reassigned as their Na complexes. The antibacterial and cytotoxic activities of 18 were also evaluated. However, because of their instability, all of the isolated compounds did not show significant antibacterial activity as the preliminary EtOAc extracts of the fungal strain. Full article
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Figures

Graphical abstract

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