Next Article in Journal
In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator
Next Article in Special Issue
Solid Matrix-Supported Supercritical CO2 Enhances Extraction of γ-Linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation of the Molecule in Zebrafish
Previous Article in Journal
5-O-Acetyl-Renieramycin T from Blue Sponge Xestospongia sp. Induces Lung Cancer Stem Cell Apoptosis
Previous Article in Special Issue
Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Marine Drugs
Volume 17
Issue 2
10.3390/md17020111
marinedrugs-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

A Multi-Bioassay Integrated Approach to Assess the Antifouling Potential of the Cyanobacterial Metabolites Portoamides

by
Jorge Antunes
1,2,
Sandra Pereira
1,
Tiago Ribeiro
1,
Jeffrey E. Plowman
3,
Ancy Thomas
3,
Stefan Clerens
3,4,5,
Alexandre Campos
1,
Vitor Vasconcelos
1,2,* and
Joana R. Almeida
1,*
1
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal
2
Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, P 4069-007 Porto, Portugal
3
AgResearch Ltd., 1365 Springs Rd, Lincoln 7674, New Zealand
4
Biomolecular Interaction Centre, University of Canterbury, Christchurch P 8140, New Zealand
5
Riddet Institute, Massey University, Palmerston North P 4442, New Zealand
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 111; https://doi.org/10.3390/md17020111
Received: 28 December 2018 / Revised: 31 January 2019 / Accepted: 8 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Compounds from Cyanobacteria II)
View Full-Text Download PDF
Browse Figures

Abstract

The cyclic peptides portoamides produced by the cyanobacterium Phormidium sp. LEGE 05292 were previously isolated and their ability to condition microcommunities by allelopathic effect was described. These interesting bioactive properties are, however, still underexplored as their biotechnological applications may be vast. This study aims to investigate the antifouling potential of portoamides, given that a challenge in the search for new environmentally friendly antifouling products is to find non-toxic natural alternatives with the ability to prevent colonization of different biofouling species, from bacteria to macroinvertebrates. A multi-bioassay approach was applied to assess portoamides antifouling properties, marine ecotoxicity and molecular mode of action. Results showed high effectiveness in the prevention of mussel larvae settlement (EC50 = 3.16 µM), and also bioactivity towards growth and biofilm disruption of marine biofouling bacterial strains, while not showing toxicity towards both target and non-target species. Antifouling molecular targets in mussel larvae include energy metabolism modifications (failure in proton-transporting ATPases activity), structural alterations of the gills and protein and gene regulatory mechanisms. Overall, portoamides reveal a broad-spectrum bioactivity towards diverse biofouling species, including a non-toxic and reversible effect towards mussel larvae, showing potential to be incorporated as an active ingredient in antifouling coatings. View Full-Text
Keywords: biofouling; antifouling; cyanobacteria; natural products; marine biofilms; mode of action biofouling; antifouling; cyanobacteria; natural products; marine biofilms; mode of action
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Antunes, J.; Pereira, S.; Ribeiro, T.; Plowman, J.E.; Thomas, A.; Clerens, S.; Campos, A.; Vasconcelos, V.; Almeida, J.R. A Multi-Bioassay Integrated Approach to Assess the Antifouling Potential of the Cyanobacterial Metabolites Portoamides. Mar. Drugs 2019, 17, 111. https://doi.org/10.3390/md17020111

AMA Style

Antunes J, Pereira S, Ribeiro T, Plowman JE, Thomas A, Clerens S, Campos A, Vasconcelos V, Almeida JR. A Multi-Bioassay Integrated Approach to Assess the Antifouling Potential of the Cyanobacterial Metabolites Portoamides. Marine Drugs. 2019; 17(2):111. https://doi.org/10.3390/md17020111

Chicago/Turabian Style

Antunes, Jorge, Sandra Pereira, Tiago Ribeiro, Jeffrey E. Plowman, Ancy Thomas, Stefan Clerens, Alexandre Campos, Vitor Vasconcelos, and Joana R. Almeida. 2019. "A Multi-Bioassay Integrated Approach to Assess the Antifouling Potential of the Cyanobacterial Metabolites Portoamides" Marine Drugs 17, no. 2: 111. https://doi.org/10.3390/md17020111

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop