Special Issue "Marine Macrolides: Structure, Biosynthetic Aspects and Potential as a New Drugs"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 15462
Interests: organic structure elucidation; stereochemistry and configurational analysis by NMR and computational methods; organic synthesis of natural products; siderophores; pathogenic bacteria in aquaculture
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Macrolides are common structural scaffolds widespread in nature. The structures of these large-ring lactones usually are very difficult to elucidate, either for the minute amounts isolated or by their intricate flexible and highly substituted skeletons. Marine organism and their symbionts have produced a large number of structurally diverse macrolides with important biological activities. The sponges are the most important source of this type of secondary metabolites; however, dinoflagellate, algae, and tunicates have been also studied and, from a chemical structure point of view, very interesting polyene backbones have been discovered.
Good examples of known marine macrolides are the bryostatins, the spongistatins, or the halichondrins, the first marine macrolides established as powerful antimitotic agents. Since then there has been extensive attention in the halichondrin family. This interest is, without doubt, due to their outstanding potential as therapeutic agent demonstrated with the development of the already approved drug erybulin mesylate (Halaven™). This halichondrin B derivative is being used for metastatic breast cancer in patients who have received at least two prior chemotherapy regimens for late stage disease.
With these precedents, the goals of the proposed Special Issue will be to show marine macrolides from three different points of view: (a) Structural elucidation of their chemical structures, (b) description of their biological activities (c) the aspects related to the biosynthesis. Synthetic approaches to their skeletons will be also considered.
Prof. Jaime Rodríguez
Manuscript Submission Information
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