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Special Issue "Marine Macrolides: Structure, Biosynthetic Aspects and Potential as a New Drug"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: 31 December 2019.
Departamento de Química, Facultade de Ciencias and Centro de Investigacions Científicas Avanzadas (CICA). Universidade da Coruña, Campus da Zapateira s/n, 15071 A Coruña, Spain
Interests: Synthesis of natural products and analogues; Applications of NMR structural analysis; Isolation and elucidation of natural products
Macrolides are common structural scaffolds widespread in nature. The structures of these large-ring lactones usually are very difficult to elucidate, either for the minute amounts isolated or by their intricate flexible and highly substituted skeletons. Marine organism and their symbionts have produced a large number of structurally diverse macrolides with important biological activities. The sponges are the most important source of this type of secondary metabolites; however, dinoflagellate, algae, and tunicates have been also studied and, from a chemical structure point of view, very interesting polyene backbones have been discovered.
Good examples of known marine macrolides are the bryostatins, the spongistatins, or the halichondrins, the first marine macrolides established as powerful antimitotic agents. Since then there has been extensive attention in the halichondrin family. This interest is, without doubt, due to their outstanding potential as therapeutic agent demonstrated with the development of the already approved drug erybulin mesylate (Halaven™). This halichondrin B derivative is being used for metastatic breast cancer in patients who have received at least two prior chemotherapy regimens for late stage disease.
With these precedents, the goals of the proposed Special Issue will be to show marine macrolides from three different points of view: (a) Structural elucidation of their chemical structures, (b) description of their biological activities (c) the aspects related to the biosynthesis. Synthetic approaches to their skeletons will be also considered.
Prof. Jaime Rodríguez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.