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Marine Drugs, Volume 16, Issue 8

August 2018 - 43 articles

Cover Story: Prionace glauca is one the major bycatch species taken from driftnet fisheries every year generating a significant amount of biomass, considered waste for the fish transformation industry that needs to be managed and ultimately valorized. Exploring the potential of blue shark byproducts, as skins and teeth, 3D bioactive structures with a huge potential for biomedical applications were fabricated. Collagen extracted from the skin of Prionace glauca combined with bioceramic particles obtained from the tooth of Prionace glauca and Iurus oxyrinchus were combined and processed by freeze-drying to produce 3D structures as biomaterials aiming at hard tissue regeneration. Based on a strategy of marine byproducts valorization the produced collagen/apatite composites demonstrate the sustainability of the structures to support and promote osteogenic lineage survival. View the paper here.
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Articles (43)

  • Feature Paper
  • Review
  • Open Access
17 Citations
7,644 Views
14 Pages

Blueprints for the Next Generation of Bioinspired and Biomimetic Mineralised Composites for Bone Regeneration

  • Pamela J. Walsh,
  • Kathryn Fee,
  • Susan A. Clarke,
  • Matthew L. Julius and
  • Fraser J. Buchanan

20 August 2018

Coccolithophores are unicellular marine phytoplankton, which produce intricate, tightly regulated, exoskeleton calcite structures. The formation of biogenic calcite occurs either intracellularly, forming ‘wheel-like’ calcite plates, or ex...

  • Article
  • Open Access
26 Citations
7,309 Views
23 Pages

Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity

  • Decha Kumla,
  • José A. Pereira,
  • Tida Dethoup,
  • Luis Gales,
  • Joana Freitas-Silva,
  • Paulo M. Costa,
  • Michael Lee,
  • Artur M. S. Silva,
  • Nazim Sekeroglu and
  • Madalena M. M. Pinto
  • + 1 author

20 August 2018

A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-ch...

  • Article
  • Open Access
63 Citations
6,979 Views
13 Pages

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

  • Young-In Kim,
  • Won-Seok Oh,
  • Phil Hyun Song,
  • Sungho Yun,
  • Young-Sam Kwon,
  • Young Joon Lee,
  • Sae-Kwang Ku,
  • Chang-Hyun Song and
  • Tae-Ho Oh

18 August 2018

Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways of inflammation and modulation of extracellular matrix remodeling proteins, collagens, and matrix...

  • Article
  • Open Access
12 Citations
4,974 Views
14 Pages

Alkaline Phosphatase Immobilization on New Chitosan Membranes with Mg2+ for Biomedical Applications

  • Gratiela Teodora Tihan,
  • Roxana Gabriela Zgarian,
  • Elena Berteanu,
  • Daniela Ionita,
  • Georgeta Totea,
  • Catalin Iordachel,
  • Rodica Tatia,
  • Mariana Prodana and
  • Ioana Demetrescu

18 August 2018

In this paper, we present the fabrication and characterization of new chitosan-based membranes while using a new biotechnology for immobilizing alkaline phosphatase (ALP). This technology involved metal ions incorporation to develop new biopolymeric...

  • Communication
  • Open Access
11 Citations
5,035 Views
9 Pages

Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea

  • Germana Esposito,
  • Roberta Teta,
  • Gerardo Della Sala,
  • Joseph R. Pawlik,
  • Alfonso Mangoni and
  • Valeria Costantino

17 August 2018

The organic extract of the Caribbean sponge Smenospongia aurea has been shown to contain an array of novel chlorinated secondary metabolites derived from a mixed PKS-NRPS biogenetic route such as the smenamides. In this paper, we report the presence...

  • Article
  • Open Access
47 Citations
5,728 Views
15 Pages

Photosynthetic Accumulation of Lutein in Auxenochlorella protothecoides after Heterotrophic Growth

  • Yibo Xiao,
  • Xi He,
  • Qi Ma,
  • Yue Lu,
  • Fan Bai,
  • Junbiao Dai and
  • Qingyu Wu

16 August 2018

In order to enhance lutein accumulation and to explain the reasons for the difference in lutein accumulation under photoautotrophic and heterotrophic conditions, different culture modes and the associated transcriptome profiles were investigated in A...

  • Article
  • Open Access
28 Citations
5,030 Views
10 Pages

Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1

  • Hao-Bing Yu,
  • Xiao-Li Wang,
  • Wei-Heng Xu,
  • Yi-Xin Zhang,
  • Yi-Sen Qian,
  • Jian-Peng Zhang,
  • Xiao-Ling Lu and
  • Xiao-Yu Liu

16 August 2018

Three new pimarane diterpenes, eutypellenoids A–C (1–3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1–3 possessed an uncomm...

  • Article
  • Open Access
24 Citations
6,415 Views
13 Pages

15 August 2018

A water-soluble low molecular–weight polysaccharide named UP2-1 was isolated and purified from the marine green algae Ulothrix flacca using ion-exchange and size-exclusion chromatography. Composition and characteristics analyses showed that UP2...

  • Communication
  • Open Access
19 Citations
5,108 Views
9 Pages

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

  • Yaqin Fan,
  • Cong Wang,
  • Liping Wang,
  • Arthit Chairoungdua,
  • Pawinee Piyachaturawat,
  • Peng Fu and
  • Weiming Zhu

15 August 2018

Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configur...

  • Review
  • Open Access
101 Citations
12,533 Views
31 Pages

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

  • Olga Maria Lage,
  • María C. Ramos,
  • Rita Calisto,
  • Eduarda Almeida,
  • Vitor Vasconcelos and
  • Francisca Vicente

14 August 2018

The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study...

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Mar. Drugs - ISSN 1660-3397