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Open AccessArticle

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

1
Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, Korea
2
Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
3
Anti-Aging Research Institute of BIO-FD&C Co. Ltd., Incheon 21990, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(8), 262; https://doi.org/10.3390/md16080262
Received: 11 July 2018 / Revised: 23 July 2018 / Accepted: 27 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue The Pharmacological Potential of Marine-Derived Peptides and Proteins)
Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS. View Full-Text
Keywords: nicotinamide; isoleucine-valine-histidine; antioxidant; nuclear factor (erythroid-derived 2)-like factor; wound-healing nicotinamide; isoleucine-valine-histidine; antioxidant; nuclear factor (erythroid-derived 2)-like factor; wound-healing
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Son, D.H.; Yang, D.J.; Sun, J.S.; Kim, S.K.; Kang, N.; Kang, J.Y.; Choi, Y.-H.; Lee, J.H.; Moh, S.H.; Shin, D.M.; Kim, K.W. A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells. Mar. Drugs 2018, 16, 262.

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