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Mar. Drugs 2018, 16(8), 264; https://doi.org/10.3390/md16080264

Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-κB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells

1
College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
2
Natural Resources and Environmental Studies Program, University of Northern British Columbia, Prince George, BC V2N 4Z9, Canada
*
Authors to whom correspondence should be addressed.
Received: 8 July 2018 / Accepted: 24 July 2018 / Published: 1 August 2018
(This article belongs to the Collection Bioactive Compounds from Marine Plankton)
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Abstract

Sargassum fusifrome is considered a “longevity vegetable” in Asia. Sargassum fusifrome polysaccharides exhibit numerous biological activities, specially, the modulation of immune response via the NF-κB signaling pathway. However, the precise mechanisms by which these polysaccharides modulate the immune response through the NF-κB signaling pathway have not been elucidated. In this study, we purified and characterized a novel fraction of Sargassum fusifrome polysaccharide and named it SFP-F2. SFP-F2 significantly upregulated the production of the cytokines TNF-α, IL-1β and IL-6 in RAW264.7 cells. It also activated the NF-κB signaling pathway. Data obtained from experiments carried out with specific inhibitors (PDTC, BAY 11-7082, IKK16 and SB203580) suggested that SFP-F2 activated the NF-κB signaling pathway via CD14/IKK and P38 axes. SFP-F2 could therefore potentially exert an immune-enhancement effect through inducing the CD14/IKK/NF-κB and P38/NF-κB signaling pathways. View Full-Text
Keywords: Sargassum fusifrome; polysaccharides; NF-κB signaling pathway; CD14; P38; RAW264.7 cell Sargassum fusifrome; polysaccharides; NF-κB signaling pathway; CD14; P38; RAW264.7 cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chen, L.; Chen, P.; Liu, J.; Hu, C.; Yang, S.; He, D.; Yu, P.; Wu, M.; Zhang, X. Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-κB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells. Mar. Drugs 2018, 16, 264.

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