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Special Issue "Bioprospecting of Marine Microorganisms"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 1 January 2019

Special Issue Editor

Guest Editor
Prof. Usama Ramadan Abdelmohsen

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
Website | E-Mail
Phone: 0049-931-3180297
Interests: marine sponges; marine actinomycetes; natural products; medicinal plants; peptides; metabolomics

Special Issue Information

Dear Colleagues,

Microorganisms are leading sources of novel compounds that have been used in the pharmaceutical industry since their discovery. Several bacterial and fungal classes are capable of synthesizing various classes of secondary metabolites. The diversity in their chemical structures (alkaloids, polyketides, peptides and terpenes), as well as their bioactivities (antifungal, antibacterial, antiviral, antiparasitic, immunomodulatory, antioxidant, anti-inflammatory, and anticancer) highlight their role in pharmaceutical and agricultural research. Since the discovery of penicillin in 1928, several microorganism-derived antibiotics have been discovered and the recent example is teixobactin. Teixobactin was identified by Ling and coworkers from a soil microorganism (provisionally named Eleftheria terrae) and represent a new class of antibiotics. The presence in those extreme environmental conditions, such as high pressure, lack of light, salinity and pH, provoke marine microorganisms to biosynthesize a unique variety of chemicals, of which a large number are still unexplored in comparison to their terrestrial counterparts, and can become a source of bioactive lead compounds.

This Special Issue “Bioprospecting of Marine Microorganisms” in Marine Drugs will cover the scope of natural products derived from marine microorganisms. Phylogenetic and diversity studies as well as new methodologies for isolating marine microorganisms will also be targeted in this Special Issue.

As Guest Editor, I encourage all researchers who are interested in marine research to contribute their latest research findings in this area. I hope that it will help to gain more knowledge about marine microorganisms as a leading source for drug discovery.

Prof. Usama Ramadan Abdelmohsen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine microorganisms
  • Natural products
  • Bioactivities
  • Marine actinomycetes
  • Marine fungi
  • Drug discovery
  • İsolation
  • Structure elucidation

Published Papers (4 papers)

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Research

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Open AccessArticle New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
Mar. Drugs 2018, 16(9), 290; https://doi.org/10.3390/md16090290
Received: 30 July 2018 / Revised: 16 August 2018 / Accepted: 17 August 2018 / Published: 21 August 2018
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Abstract
A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with
[...] Read more.
A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with the marine sponge Callyspongia sp. from the Red Sea. The structure elucidation of the isolated compounds were determined based on detailed spectroscopic data including 1D and 2D nuclear magnetic resonance (NMR) experimental analyses in combination with high resolution electrospray ionization mass spectrometry (HR-ESI-MS), while the absolute stereochemistry of all amino acids components of nocardiotide A (1) was deduced using Marfey’s method. Additionally, ten known metabolites were dereplicated using HR-ESI-MS analysis. Nocardiotide A (1) displayed significant cytotoxic effects towards the murine CT26 colon carcinoma, human HeLa cervix carcinoma, and human MM.1S multiple myeloma cell lines. The results obtained revealed sponge-associated Nocardiopsis as a substantial source of lead natural products with pronounced pharmacological activities. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Microorganisms)
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Open AccessArticle First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86
Mar. Drugs 2018, 16(8), 270; https://doi.org/10.3390/md16080270
Received: 24 July 2018 / Revised: 31 July 2018 / Accepted: 2 August 2018 / Published: 4 August 2018
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Abstract
The production of secondary metabolites by a new isolate of the purple sulfur bacterium Allochromatium vinosum, which had shown antibiotic activities during a preliminary study, revealed the production of several metabolites. Growth conditions suitable for the production of one of the compounds
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The production of secondary metabolites by a new isolate of the purple sulfur bacterium Allochromatium vinosum, which had shown antibiotic activities during a preliminary study, revealed the production of several metabolites. Growth conditions suitable for the production of one of the compounds shown in the metabolite profile were established and compound 1 was purified. The molecular formula of compound 1 (C20H28O2) was determined by high resolution mass spectra, and its chemical structure by means of spectroscopic methods. The evaluation of these data revealed that the structure of the compound was identical to dehydroabietic acid, a compound known to be characteristically produced by conifer trees, but so far not known from bacteria, except cyanobacteria. The purified substance showed weak antibiotic activities against Bacillus subtilis and Staphylococcus lentus with IC50 values of 70.5 µM (±2.9) and 57.0 µM (±3.3), respectively. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Microorganisms)
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Open AccessArticle Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348
Mar. Drugs 2017, 15(12), 383; https://doi.org/10.3390/md15120383
Received: 25 October 2017 / Revised: 6 November 2017 / Accepted: 16 November 2017 / Published: 6 December 2017
Cited by 3 | PDF Full-text (560 KB) | HTML Full-text | XML Full-text
Abstract
A new cyclic dipeptide, petrocidin A (1), along with three known compounds—2,3-dihydroxybenzoic acid (2), 2,3-dihydroxybenzamide (3), and maltol (4)—were isolated from the solid culture of Streptomyces sp. SBT348. The strain Streptomyces sp. SBT348 had been
[...] Read more.
A new cyclic dipeptide, petrocidin A (1), along with three known compounds—2,3-dihydroxybenzoic acid (2), 2,3-dihydroxybenzamide (3), and maltol (4)—were isolated from the solid culture of Streptomyces sp. SBT348. The strain Streptomyces sp. SBT348 had been prioritized in a strain collection of 64 sponge-associated actinomycetes based on its distinct metabolomic profile using liquid chromatography/high-resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR). The absolute configuration of all α-amino acids was determined by HPLC analysis after derivatization with Marfey’s reagent and comparison with commercially available reference amino acids. Structure elucidation was pursued in the presented study by mass spectrometry and NMR spectral data. Petrocidin A (1) and 2,3-dihydroxybenzamide (3) exhibited significant cytotoxicity towards the human promyelocytic HL-60 and the human colon adenocarcinoma HT-29 cell lines. These results demonstrated the potential of sponge-associated actinomycetes for the discovery of novel and pharmacologically active natural products. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Microorganisms)
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Review

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Open AccessReview Natural Product Potential of the Genus Nocardiopsis
Mar. Drugs 2018, 16(5), 147; https://doi.org/10.3390/md16050147
Received: 1 April 2018 / Revised: 25 April 2018 / Accepted: 26 April 2018 / Published: 29 April 2018
Cited by 1 | PDF Full-text (1230 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Actinomycetes are a relevant source of novel bioactive compounds. One of the pharmaceutically and biotechnologically important genera that attract natural products research is the genus Nocardiopsis, mainly for its ability to produce a wide variety of secondary metabolites accounting for its wide range
[...] Read more.
Actinomycetes are a relevant source of novel bioactive compounds. One of the pharmaceutically and biotechnologically important genera that attract natural products research is the genus Nocardiopsis, mainly for its ability to produce a wide variety of secondary metabolites accounting for its wide range of biological activities. This review covers the literature from January 2015 until February 2018 making a complete survey of all the compounds that were isolated from the genus Nocardiopsis, their biological activities, and natural sources, whenever applicable. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Microorganisms)
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