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Special Issue "Terpenoids from Marine Organisms"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 20 March 2019

Special Issue Editors

Guest Editor
Assist. Prof. Efstathia Ioannou

Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
Website | E-Mail
Phone: +302107274913
Interests: marine natural products; structure elucidation; bioactivity evaluation; marine-derived microorganisms; biotransformations
Guest Editor
Prof. Vassilios Roussis

Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, GR 15771, Athens, Greece
E-Mail
Phone: +30210 7274 592
Fax: +30 210 7274 592
Interests: marine natural products; chemotaxonomy; chemical ecology

Special Issue Information

Dear Colleagues,

Marine natural products have enjoyed a renaissance in the past few years, displaying molecules that have been approved as drugs in the United States and the European Union, as well as a diverse array of compounds that are currently into clinical trials.

Terpenes, one of the most diverse classes of natural products produced by a variety of organisms, are vital for the life of most organisms, exerting metabolic control and mediating intra- and inter-species interactions. More than 40,000 individual terpenoids are known to exist in nature with new compounds being discovered every year.

Marine organisms produce a wide array of fascinating terpenoid structures distinguished by characteristic structural features. The biological and ecochemical functions of terpenes include chemical communication, pollination, chemical protection, growth regulation, among others, but even though numerous studies have been reported on this subject, the full spectrum of their ecological roles has not yet been fully clarified.

Potential challenges and future directions involved in the advancement of these promising natural compounds will be covered in the special issue, including isolation-structure elucidation of new molecules, metabolomic studies, evaluation of bioactivities, mechanisms of action, recent developments in their biosynthesis, total synthesis, semisynthesis and biotransformatiom, as well as pharmaceutical applications.

Assist. Prof. Efstathia Ioannou
Prof. Vassilios Roussis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Terpenes

  • Bioactivity

  • Biosynthesis

  • Metabolomic studies

  • Synthesis

  • Biotransformations

  • Pharmaceutical applications

  • Ecological roles

Published Papers (5 papers)

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Research

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Open AccessArticle Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1
Mar. Drugs 2018, 16(8), 284; https://doi.org/10.3390/md16080284
Received: 29 July 2018 / Revised: 12 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
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Abstract
Three new pimarane diterpenes, eutypellenoids A–C (13), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 13 possessed an uncommon
[...] Read more.
Three new pimarane diterpenes, eutypellenoids A–C (13), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 13 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 μg/mL, respectively. Additionally, compound 2 showed antifungal activity against Candida parapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 μg/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 μM. Full article
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Open AccessArticle New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
Mar. Drugs 2018, 16(8), 276; https://doi.org/10.3390/md16080276
Received: 27 June 2018 / Revised: 24 July 2018 / Accepted: 31 July 2018 / Published: 6 August 2018
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Abstract
Six new cembranoids, cherbonolides A−E (15) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by
[...] Read more.
Six new cembranoids, cherbonolides A−E (15) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 17 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. Full article
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Graphical abstract

Open AccessCommunication Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor
Mar. Drugs 2018, 16(6), 177; https://doi.org/10.3390/md16060177
Received: 17 April 2018 / Revised: 14 May 2018 / Accepted: 14 May 2018 / Published: 23 May 2018
PDF Full-text (2858 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (37) and a known compound asperdemin (8), were obtained from the marine-derived fungus
[...] Read more.
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (37) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Full article
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Open AccessArticle Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells
Mar. Drugs 2018, 16(5), 166; https://doi.org/10.3390/md16050166
Received: 24 April 2018 / Revised: 8 May 2018 / Accepted: 14 May 2018 / Published: 16 May 2018
PDF Full-text (12771 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Cutaneous melanoma is the most serious type of skin cancer, so new cytotoxic weapons against novel targets in melanoma are of great interest. Euplotin C (EC), a cytotoxic secondary metabolite of the marine ciliate Euplotes crassus, was evaluated in the present study
[...] Read more.
Cutaneous melanoma is the most serious type of skin cancer, so new cytotoxic weapons against novel targets in melanoma are of great interest. Euplotin C (EC), a cytotoxic secondary metabolite of the marine ciliate Euplotes crassus, was evaluated in the present study on human cutaneous melanoma cells to explore its anti-melanoma activity and to gain more insight into its mechanism of action. EC exerted a marked cytotoxic effect against three different human melanoma cell lines (A375, 501Mel and MeWo) with a potency about 30-fold higher than that observed in non-cancer cells (HDFa cells). A pro-apoptotic activity and a decrease in melanoma cell migration by EC were also observed. At the molecular level, the inhibition of the Erk and Akt pathways, which control many aspects of melanoma aggressiveness, was shown. EC cytotoxicity was antagonized by dantrolene, a ryanodine receptor (RyR) antagonist, in a concentration-dependent manner. A role of RyR as a direct target of EC was also suggested by molecular modelling studies. In conclusion, our data provide the first evidence of the anti-melanoma activity of EC, suggesting it may be a promising new scaffold for the development of selective activators of RyR to be used for the treatment of melanoma and other cancer types. Full article
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Review

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Open AccessReview Terpenoids from Marine Soft Coral of the Genus Lemnalia: Chemistry and Biological Activities
Mar. Drugs 2018, 16(9), 320; https://doi.org/10.3390/md16090320
Received: 2 August 2018 / Revised: 2 September 2018 / Accepted: 4 September 2018 / Published: 9 September 2018
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Abstract
Lemnalia is one of the most widely-distributed marine soft coral in tropical oceans and is known to produce novel terpenoids with a broad spectrum of biological activities. This review provides the first comprehensive overview of terpenoids produced by soft coral Lemnalia since their
[...] Read more.
Lemnalia is one of the most widely-distributed marine soft coral in tropical oceans and is known to produce novel terpenoids with a broad spectrum of biological activities. This review provides the first comprehensive overview of terpenoids produced by soft coral Lemnalia since their first discovery in 1974. Full article
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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