Next Article in Journal
Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea
Next Article in Special Issue
Terpenoids from Marine Soft Coral of the Genus Lemnalia: Chemistry and Biological Activities
Previous Article in Journal
Photosynthetic Accumulation of Lutein in Auxenochlorella protothecoides after Heterotrophic Growth
Previous Article in Special Issue
New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(8), 284;

Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1

Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, China
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, CA 92093, USA
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
School of Physical Sciences, University of California, Irvine, CA 92697, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 29 July 2018 / Revised: 12 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
Full-Text   |   PDF [4225 KB, uploaded 18 August 2018]   |  


Three new pimarane diterpenes, eutypellenoids A–C (13), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 13 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 μg/mL, respectively. Additionally, compound 2 showed antifungal activity against Candida parapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 μg/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 μM. View Full-Text
Keywords: Arctic fungus; Eutypella sp.; pimarane diterpene; bioactivity Arctic fungus; Eutypella sp.; pimarane diterpene; bioactivity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Yu, H.-B.; Wang, X.-L.; Xu, W.-H.; Zhang, Y.-X.; Qian, Y.-S.; Zhang, J.-P.; Lu, X.-L.; Liu, X.-Y. Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1. Mar. Drugs 2018, 16, 284.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top