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Mar. Drugs 2018, 16(8), 276; https://doi.org/10.3390/md16080276

New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
4
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
5
Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
6
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
7
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
8
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
*
Author to whom correspondence should be addressed.
Received: 27 June 2018 / Revised: 24 July 2018 / Accepted: 31 July 2018 / Published: 6 August 2018
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Abstract

Six new cembranoids, cherbonolides A−E (15) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 17 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. View Full-Text
Keywords: Sarcophyton cherbonnieri; cembranoid; biscembranoid peroxide; anti-inflammatory activity; elastase release inhibition Sarcophyton cherbonnieri; cembranoid; biscembranoid peroxide; anti-inflammatory activity; elastase release inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Peng, C.-C.; Huang, C.-Y.; Ahmed, A.F.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri. Mar. Drugs 2018, 16, 276.

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