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Mar. Drugs 2018, 16(8), 270; https://doi.org/10.3390/md16080270

First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86

1
Department of Marine Microbiology, GEOMAR Helmholtz Centre for Ocean Research Kiel, 24105 Kiel, Germany
2
Shenzhen Key Lab of Marine Genomics, BGI Fisheries, BGI, Building No.11, Beishan Industrial Zon, Yantian District, Shenzhen 518083, China
3
Department of Biological Sciences, Tokyo Metropolitan University, Hachioji-shi, Tokyo 192-0397, Japan
4
Bioviotica Naturstoffe GmbH, 37127 Dransfeld, Germany
*
Author to whom correspondence should be addressed.
Received: 24 July 2018 / Revised: 31 July 2018 / Accepted: 2 August 2018 / Published: 4 August 2018
(This article belongs to the Special Issue Bioprospecting of Marine Microorganisms)
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Abstract

The production of secondary metabolites by a new isolate of the purple sulfur bacterium Allochromatium vinosum, which had shown antibiotic activities during a preliminary study, revealed the production of several metabolites. Growth conditions suitable for the production of one of the compounds shown in the metabolite profile were established and compound 1 was purified. The molecular formula of compound 1 (C20H28O2) was determined by high resolution mass spectra, and its chemical structure by means of spectroscopic methods. The evaluation of these data revealed that the structure of the compound was identical to dehydroabietic acid, a compound known to be characteristically produced by conifer trees, but so far not known from bacteria, except cyanobacteria. The purified substance showed weak antibiotic activities against Bacillus subtilis and Staphylococcus lentus with IC50 values of 70.5 µM (±2.9) and 57.0 µM (±3.3), respectively. View Full-Text
Keywords: anoxygenic phototrophic bacteria (APB); Allochromatium vinosum; secondary metabolites; dehydroabietic acid; antibiotic anoxygenic phototrophic bacteria (APB); Allochromatium vinosum; secondary metabolites; dehydroabietic acid; antibiotic
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Imhoff, J.F.; Sun, M.; Wiese, J.; Tank, M.; Zeeck, A. First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86. Mar. Drugs 2018, 16, 270.

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