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Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling

1
Laboratory of Food Function and Biochemistry, Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University, Shimonoseki 759-6595, Japan
2
Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University, Tsu 514-8507, Japan
3
Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University, Tsu 514-8507, Japan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(8), 267; https://doi.org/10.3390/md16080267
Received: 3 July 2018 / Revised: 21 July 2018 / Accepted: 28 July 2018 / Published: 2 August 2018
Phlorotannin is the collective term for polyphenols derived from brown algae belonging to the genera Ascopyllum, Ecklonia, Eisenia, Fucus and Sargassum etc. Since the incidence of allergies is currently increasing in the world, there is a focus on phlorotannins having anti-allergic and anti-inflammatory effects. In this study, six purified phlorotannins (eckol; 6,6′-bieckol; 6,8′-bieckol; 8,8′-bieckol; phlorofucofuroeckol (PFF)-A and PFF-B) from Eisenia arborea, orally administered to mice, were examined for their suppression effects on ear swelling. In considering the suppression, we also examined whether the phlorotannins suppressed release of chemical mediators (histamine, leukotriene B4 and prostaglandin E2), and mRNA expression and/or the activity of cyclooxygenase-2 (COX-2), using RBL-2H3 cells, a cultured mast cell model. Results showed that the phlorotnannins exhibited suppression effects in all experiments, with 6,8′-bieckol, 8,8′-bieckol and PFF-A showing the strongest of these effects. In conclusion, orally administered phlorotannins suppress mouse ear swelling, and this mechanism apparently involves suppression of chemical mediator release and COX-2 mRNA expression or activity. This is the first report of the anti-allergic effects of the orally administered purified phlorotannins in vivo. Phlorotannins show potential for use in functional foods or drugs. View Full-Text
Keywords: brown algae; phlorotannins; anti-allergy; mouse ear swelling; arachidonic acid cascade; chemical mediators brown algae; phlorotannins; anti-allergy; mouse ear swelling; arachidonic acid cascade; chemical mediators
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Sugiura, Y.; Usui, M.; Katsuzaki, H.; Imai, K.; Kakinuma, M.; Amano, H.; Miyata, M. Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling. Mar. Drugs 2018, 16, 267.

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