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Marine Drugs, Volume 13, Issue 3

March 2015 - 28 articles

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Articles (28)

  • Article
  • Open Access
26 Citations
7,509 Views
12 Pages

The Marine Metabolite SZ-685C Induces Apoptosis in Primary Human Nonfunctioning Pituitary Adenoma Cells by Inhibition of the Akt Pathway in Vitro

  • Xin Wang,
  • Ting Tan,
  • Zhi-Gang Mao,
  • Ni Lei,
  • Zong-Ming Wang,
  • Bin Hu,
  • Zhi-Yong Chen,
  • Zhi-Gang She,
  • Yong-Hong Zhu and
  • Hai-Jun Wang

23 March 2015

Nonfunctioning pituitary adenoma (NFPA) is one of the most common types of pituitary adenoma. The marine anthraquinone derivative SZ-685C has been isolated from the secondary metabolites of the mangrove endophytic fungus Halorosellinia sp. (No. 1403)...

  • Correction
  • Open Access
5,063 Views
4 Pages

20 March 2015

The authors wish to make the following corrections to this paper [1]: Due to duplicated and missing data in Table 3, Page 5533, replace: [...]

  • Article
  • Open Access
43 Citations
8,515 Views
17 Pages

Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells

  • J. Brian Morgan,
  • Yang Liu,
  • Veena Coothankandaswamy,
  • Fakhri Mahdi,
  • Mika B. Jekabsons,
  • William H. Gerwick,
  • Frederick A. Valeriote,
  • Yu-Dong Zhou and
  • Dale G. Nagle

20 March 2015

The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for...

  • Review
  • Open Access
96 Citations
14,672 Views
29 Pages

Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications

  • Adnan A. Badwan,
  • Iyad Rashid,
  • Mahmoud M.H. Al Omari and
  • Fouad H. Darras

19 March 2015

Despite the numerous uses of chitin and chitosan as new functional materials of high potential in various fields, they are still behind several directly compressible excipients already dominating pharmaceutical applications. There are, however, new a...

  • Article
  • Open Access
7 Citations
7,220 Views
16 Pages

Mechanistic Insight into the Elastin Degradation Process by the Metalloprotease Myroilysin from the Deep-Sea Bacterium Myroides profundi D25

  • Jie Yang,
  • Hui-Lin Zhao,
  • Bai-Lu Tang,
  • Xiu-Lan Chen,
  • Hai-Nan Su,
  • Xi-Ying Zhang,
  • Xiao-Yan Song,
  • Bai-Cheng Zhou,
  • Bin-Bin Xie and
  • Anthony S. Weiss
  • + 1 author

18 March 2015

Elastases have been widely studied because of their important uses as medicine and meat tenderizers. However, there are relatively few studies on marine elastases. Myroilysin, secreted by Myroides profundi D25 from deep-sea sediment, is a novel elast...

  • Review
  • Open Access
98 Citations
11,367 Views
22 Pages

Toxic Picoplanktonic Cyanobacteria—Review

  • Natalia Jakubowska and
  • Elżbieta Szeląg-Wasielewska

18 March 2015

Cyanobacteria of a picoplanktonic cell size (0.2 to 2.0 µm) are common organisms of both freshwater and marine ecosystems. However, due to their small size and relatively short study history, picoplanktonic cyanobacteria, in contrast to the microplan...

  • Article
  • Open Access
72 Citations
8,582 Views
19 Pages

A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensis KUFA 0013

  • Chadaporn Prompanya,
  • Carla Fernandes,
  • Sara Cravo,
  • Madalena M. M. Pinto,
  • Tida Dethoup,
  • Artur M. S. Silva and
  • Anake Kijjoa

17 March 2015

A new isocoumarin derivative, similanpyrone C (1), a new cyclohexapeptide, similanamide (2), and a new pyripyropene derivative, named pyripyropene T (3) were isolated from the ethyl acetate extract of the culture of the marine sponge-associated fungu...

  • Article
  • Open Access
11 Citations
6,689 Views
15 Pages

17 March 2015

The anti-proliferative effects of diatoms, described for the first time in copepods, have also been demonstrated in benthic invertebrates such as polychaetes, sea urchins and tunicates. In these organisms PUAs (polyunsaturated aldehydes) induce the d...

  • Article
  • Open Access
13 Citations
6,920 Views
15 Pages

Purification and Partial Characterization of a New Antitumor Protein from Tegillarca granosa

  • Shuangshuang Lv,
  • Jingjing Gao,
  • Ting Liu,
  • Jianhua Zhu,
  • Jian Xu,
  • Liyan Song,
  • Jincai Liang and
  • Rongmin Yu

17 March 2015

A new protein, coded as D2-3, was obtained from the marine organism Tegillarca granosa L. by anion exchange and hydrophobic chromatography. The purity of D2-3 was over 99.0% as measured by RP-HPLC. Its molecular weight was shown to be 20.320 kDa by E...

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Mar. Drugs - ISSN 1660-3397