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International Journal of Molecular Sciences, Volume 23, Issue 21

November-1 2022 - 954 articles

Cover Story: Neuroinflammation induces neurometabolic alterations and increases in energy consumption. The orexigenic hormone Ghrelin regulates energy balance, obesity, neuroinflammation and the occurrence of neurodegenerative diseases also acting on microglia. Microglia may be regarded as important therapeutic targets in neuroinflammation as they are able to produce a wide range of chemokines involved in the inflammatory processes of the central nervous system. Together, Ghrelin and microglia are involved in the pathophysiology of neurodegenerative diseases characterized by neuronal damage such as Alzheimer’s disease and Parkinson’s disease. Particularly, Ghrelin induces these cells towards an anti-inflammatory phenotype during obesity-induced neuroinflammation. Understanding this peptide’s functions will allow for the development of new therapeutic and neurological diagnostic strategies. View this paper
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Articles (954)

  • Article
  • Open Access
7 Citations
4,164 Views
13 Pages

The Amino Acid Permease MoGap1 Regulates TOR Activity and Autophagy in Magnaporthe oryzae

  • Changli Huang,
  • Lin Li,
  • Lei Wang,
  • Jiandong Bao,
  • Xiaozhi Zhang,
  • Jiongyi Yan,
  • Jiaqi Wu,
  • Na Cao,
  • Jiaoyu Wang and
  • Fucheng Lin
  • + 3 authors

7 November 2022

Rice is an important food crop all over the world. It can be infected by the rice blast fungus Magnaporthe oryzae, which results in a significant reduction in rice yield. The infection mechanism of M. oryzae has been an academic focus for a long time...

  • Article
  • Open Access
8 Citations
3,530 Views
16 Pages

Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts

  • Fabiana Baganha,
  • Thijs J. Sluiter,
  • Rob C. M. de Jong,
  • Louise A. van Alst,
  • Hendrika A. B. Peters,
  • J. Wouter Jukema,
  • Mirela Delibegovic,
  • Knut Pettersson,
  • Paul H. A. Quax and
  • Margreet R. de Vries

7 November 2022

Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by natural IgM antibodies and low levels of these antibodies have been associate...

  • Review
  • Open Access
11 Citations
5,157 Views
17 Pages

7 November 2022

Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the...

  • Article
  • Open Access
4 Citations
3,141 Views
17 Pages

De Novo Transcriptome Assembly and Analysis of Longevity Genes Using Subterranean Termite (Reticulitermes chinensis) Castes

  • Haroon,
  • Yu-Xin Li,
  • Chen-Xu Ye,
  • Jian Su,
  • Ghulam Nabi,
  • Xiao-Hong Su and
  • Lian-Xi Xing

7 November 2022

The longevity phenomenon is entirely controlled by the insulin signaling pathway (IIS-pathway). Both vertebrates and invertebrates have IIS-pathways that are comparable to one another, though no one has previously described de novo transcriptome asse...

  • Article
  • Open Access
14 Citations
4,140 Views
22 Pages

Preliminary Expression Analysis of the OSCA Gene Family in Maize and Their Involvement in Temperature Stress

  • Yuanyang Li,
  • Yubin Zhang,
  • Bin Li,
  • Liyuan Hou,
  • Jianing Yu,
  • Chengguo Jia,
  • Zhe Wang,
  • Siqi Chen,
  • Mingzhe Zhang and
  • Wuliang Shi
  • + 2 authors

7 November 2022

Hyperosmolality-gated calcium-permeable channels (OSCA) are characterized as an osmosensor in plants; they are able to recognize and respond to exogenous and endogenous osmotic changes, and play a vital role in plant growth and adaptability to enviro...

  • Review
  • Open Access
49 Citations
16,633 Views
19 Pages

7 November 2022

Helicobacter pylori (H. pylori) is transmitted primarily through the oral–oral route and fecal–oral route. The oral cavity had therefore been hypothesized as an extragastric reservoir of H. pylori, owing to the presence of H. pylori DNA a...

  • Article
  • Open Access
5 Citations
3,396 Views
17 Pages

Fine Mapping and Candidate Gene Analysis of Pm36, a Wild Emmer-Derived Powdery Mildew Resistance Locus in Durum Wheat

  • Domenica Nigro,
  • Antonio Blanco,
  • Luciana Piarulli,
  • Massimo Antonio Signorile,
  • Pasqualina Colasuonno,
  • Emanuela Blanco and
  • Rosanna Simeone

7 November 2022

Powdery mildew (PM) is an economically important foliar disease of cultivated cereals worldwide. The cultivation of disease-resistant varieties is considered the most efficient, sustainable and economical strategy for disease management. The objectiv...

  • Article
  • Open Access
13 Citations
3,062 Views
23 Pages

7 November 2022

This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the externa...

  • Review
  • Open Access
8 Citations
4,166 Views
34 Pages

7 November 2022

Hematologic malignancies are a large and heterogeneous group of neoplasms characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic mechanisms and specifically, histone modifications, has been demonstrated to play a cent...

  • Article
  • Open Access
170 Citations
13,708 Views
15 Pages

Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment

  • Pivian Sim,
  • Xanthe L. Strudwick,
  • YunMei Song,
  • Allison J. Cowin and
  • Sanjay Garg

7 November 2022

There has been little understanding of acidification functionality in wound healing, highlighting the need to study the efficacy of wound acidification on wound closure and cellular activity in non-infected wounds. This study is focused on establishi...

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Int. J. Mol. Sci. - ISSN 1422-0067