Special Issue "HMG Proteins in Development and Disease"
Deadline for manuscript submissions: 31 December 2019.
Dr. Riccardo Sgarra
Dr. Sabrina Battista
Prof. Manfioletti Guidalberto
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
Website | E-Mail
Interests: high mobility group A (HMGA) proteins; chromatin; regulation of gene expression; protein–protein interactions; post-translational modifications (PTMs); epithelial–mesenchymal transition; proteomics; tumor microenvironment; breast cancer; metastasis
The High Mobility Group (HMG) proteins are chromatin architectural proteins subdivided into three distinct superfamilies: HMGA, HMGB, and HMGN. Each of them has specific and unusual relaxed interaction properties that enable them to interact with different DNA/chromatin sites and several cellular factors. These properties make them relevant hubs in the cellular network; indeed, they have been demonstrated to be key factors in different processes such as transcriptional regulation, embryonic development, cell signalling, DNA repair, apoptosis, maintenance of stemness, and senescence. As a consequence, HMG deregulations and misexpression lead to the development of several diseases/pathologies such as cancer, inflammation, and metabolic-related disorders. Moreover, during the last decades HMG have been demonstrated to have also extra nuclear functions, and indeed they have been found to be present in the cytoplasm and to be secreted/released in the extracellular environment. These peculiarities have significantly enlarged their already huge impact on cellular biology.
This Special Issue of IJMS will focus on the role HMG proteins play in development and disease. Articles submitted can either be original works regarding HMG functional/structural insight or full reviews; however, we kindly encourage authors to provide short and highly focused reviews on specific and hot topics related to HMGA, HMGB, or HMGN proteins.Dr. Riccardo Sgarra
Dr. Sabrina Battista
Prof. G. Manfioletti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- High Mobility Group proteins
- chromatin architecture
- regulatory networks
- HMG box
- nucleosome binding domain
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Therapeutic strategies targeting HMGB1 to treat
Authors: Sajjad Muhammad, Shafqat Rasul Chaudhry, Nima Etminan, Mika Niemelä and Daniel Hänggi
Title: HMG proteins, from genome architects and regulators to strong inflammatory instigators
Authors: Carme Barrot-Feixat and Jovita Mezquita-Pla
Title: High Mobility Group Box 1 and TLR4 Pathway in the intestine in Gnotobiotic Piglets Colonized/Infected with L. amylovorus, L. mucosae, E. coli Nissle 1917 and S. Typhimurium
Authors: Igor Splichal, Sharon M. Donovan, Vera Jenistova, Iva Splichalova, Eva Vlkova, Vera Neuzil Bunesova, Jiri Killer, Roman Svejstil, Eva Skrivanova, Alla Splichalova *
Title: Role of HMGB1 in Liver Pathogenesis
Authors: Bilon Khambu and Xiao-Ming Yin
Title: HMGA genes and proteins in development and evolution
Authors: Robert Vignali, Silvia Marracci
Title: Clinical Implications of Extracellular HMGA1 in Breast Cancer
Authors: Olga Méndez, Esther Zamora, Cristina Saura, Javier Cortés and Josep Villanueva
Title: Effect of HMGB1 mediated inflammation in hyperglycemic cardiac cells
Authors: Vikram Thakur, Binata Joddar and Munmun Chattopadhyay *
Title: The role of the mammalian high mobility group protein AT-hook 2 (HMGA2) in adipogenesis
Authors: Linjia Su and Fenfei Leng
Title: HMGA proteins in stem cell fate
Authors: S. Parisi *, D. Castaldo, F. Passaro, G. Minopoli, T. Russo