Special Issue "Protein Synthesis and Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2020).
Interests: translational control; selective translation; RNA binding proteins; subcellular localization; signaling pathways; apoptosis; mitochondrial disease
The ability of cells to adapt to stress is crucial for their survival. The stress conditions that cells must respond to—such as hypoxia, inflammation, and drug exposure—often feature prominently in varied pathological states such as cancer, diabetes, and obesity. One of the key cellular adaptation strategies that have evolved to allow organisms to respond to such conditions includes the regulation of protein synthesis (mRNA translation), providing the rapid and reversible regulation of the cellular proteome. Closely regulated protein synthesis plays a central role in virtually all fundamental biological processes; conversely, dysregulated translation has been implicated in disease pathogenesis. Although protein synthesis has been studied for over eight decades, the basic mechanistic underpinnings of gene expression regulation at the translation level during pathological conditions are still not completely understood.
This Special Issue, “Protein Synthesis and Disease”, will cover a selection of recent research topics and current review articles specifically examining the role of dysregulated protein synthesis in disease.
Prof. Martin Holcik
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mRNA translation
- Protein synthesis and cellular stress response
- Protein synthesis and human disease
- Mitochondrial protein synthesis
- Targeting translation for therapy