Special Issue "Mitochondria-Targeted Approaches in Health and Disease"
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 19568
Interests: mitochondria; reactive oxygen species; oxidative stress; aging; ischemia; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue in Brain Sciences: Mitochondria as Therapeutic Target for Acute Brain Pathologies
Special Issue in International Journal of Molecular Sciences: Mitochondria-Targeted Approaches in Health and Disease 2.0
Topical Collection in International Journal of Molecular Sciences: State-of-the-Art Biochemistry in Russia
Mitochondria are one of the most intriguing intracellular elements. Apart from their great contribution to cellular bioenergetics, they perform various unique functions (both synthetic and regulatory). Now, it has become clear that mitochondrial fitness is the prerequisite of a healthy cell. Inherited or acquired mitochondrial disfunction caused by changes in the genetic, lepidic, and proteinaceous content causing abnormal changes in structure and functions, can be detrimental or even fatal for a cell. The intrinsic mechanism of mitochondrial quality control realizes the detection of unfitted mitochondria or their elements with their elimination from the cell, ultimately performing clearing the system of abnormal mitochondrial structures. However, because of intrinsic and extrinsic challenges, this machinery misses the mitochondrial defects yielding the co-existance of normal and abnormal mitochondria within a single cell, which is a main index of diseases and aging. To avoid an unnecessary appearance of unhealthy mitochondrial population in the cell when intrinsic mechanisms of reparation are partially or completely failed, various approaches have been successfully developed. The goal of the proposed Special Issue, Mitochondria-Targeted Approaches in Health and Disease, is to collect all of the possible methods of intervention into mitochondrial functioning, so as to prevent or repair unwanted changes in the mitochondrial structure and function.
Prof. Dr. Dmitry B Zorov
Manuscript Submission Information
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- membrane potential
- ATP synthase
- quality control
- population analysis
- reactive oxygen species
- respiratory chain