Special Issue "Mitochondria-Targeted Approaches in Health and Disease"
Deadline for manuscript submissions: closed (31 March 2020).
Interests: mitochondria; reactive oxygen species; oxidative stress; aging; ischemia; inflammation
Special Issues and Collections in MDPI journals
Special Issue in Brain Sciences: Mitochondria as Therapeutic Target for Acute Brain Pathologies
Mitochondria are one of the most intriguing intracellular elements. Apart from their great contribution to cellular bioenergetics, they perform various unique functions (both synthetic and regulatory). Now, it has become clear that mitochondrial fitness is the prerequisite of a healthy cell. Inherited or acquired mitochondrial disfunction caused by changes in the genetic, lepidic, and proteinaceous content causing abnormal changes in structure and functions, can be detrimental or even fatal for a cell. The intrinsic mechanism of mitochondrial quality control realizes the detection of unfitted mitochondria or their elements with their elimination from the cell, ultimately performing clearing the system of abnormal mitochondrial structures. However, because of intrinsic and extrinsic challenges, this machinery misses the mitochondrial defects yielding the co-existance of normal and abnormal mitochondria within a single cell, which is a main index of diseases and aging. To avoid an unnecessary appearance of unhealthy mitochondrial population in the cell when intrinsic mechanisms of reparation are partially or completely failed, various approaches have been successfully developed. The goal of the proposed Special Issue, Mitochondria-Targeted Approaches in Health and Disease, is to collect all of the possible methods of intervention into mitochondrial functioning, so as to prevent or repair unwanted changes in the mitochondrial structure and function.
Prof. Dr. Dmitry B Zorov
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- membrane potential
- ATP synthase
- quality control
- population analysis
- reactive oxygen species
- respiratory chain