PPARs in Metabolic Regulation: Implications for Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 150748
Special Issue Editors
2. Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland
Interests: nuclear receptor superfamily; gene regulation and gene expression profiling; metabolic regulations; development; skin and wound healing; cancer; liver physiology; non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); adipose tissue; muscle and exercise; gut; microbiota; inter-organ cross-talk; nutrition; nutrigenetics and nutrigenomics
Special Issues, Collections and Topics in MDPI journals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
This Special Issue is the continuation of our previous special issue "PPARs in Cellular and Whole Body Energy Metabolism".
According to the World Health Organization, noncommunicable diseases (NCDs) kill 41 million people each year, equivalent to more than 70% of all deaths worldwide. In general, these diseases are of long duration and are the result of a combination of genetic, physiological, lifestyle (nutrition, sedentarity), and environmental factors. There is mounting evidence that a group of related transcription factors, the nuclear receptors called peroxisome proliferator-activated receptors (PPARs), are involved in some of these chronic diseases, such as obesity, diabetes, cardiovascular diseases, and cancer. PPAR activity is modulated not only by fatty acids and their derivatives, but also by drugs such as thiazolidinediones and fibrates, which has instigated an extraordinary research effort for understanding the roles of PPARs in health and disease, more particularly through metabolic regulation. This Special Issue of IJMS will cover the latest developments in the physiological functions of PPARs in all organs, including their responses to nutrition and physical activity. It will explore processes regulated by PPARs, which are implicated in cellular and whole-organism metabolism. How key roles of PPARs in healthy and diseased organisms can be modulated to maintain or improve the optimal health of individuals and populations is of foremost interest.
Prof. Dr. Walter Wahli
Ms. Rachel Tee
Guest Editors
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Keywords
- Peroxisome Proliferator-Activated Receptors (PPARs)
- Energy homeostasis
- Metabolic regulations
- Organ cross-talk
- Lipids and carbohydrates
- Metabolic diseases
- Cancer and reprogramming of energy metabolism
- Systems biology
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