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Open AccessReview

TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches

1
Department of Physiology, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary
2
Institute of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nürnberg, Universitätsstr. 17, D-91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 342; https://doi.org/10.3390/ijms21010342
Received: 12 December 2019 / Revised: 31 December 2019 / Accepted: 2 January 2020 / Published: 4 January 2020
(This article belongs to the Special Issue Capsaicin and TRPV1 in the Study of Pain and Organ Pathologies)
Pain in trigeminal areas is driven by nociceptive trigeminal afferents. Transduction molecules, among them the nonspecific cation channels transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1), which are activated by endogenous and exogenous ligands, are expressed by a significant population of trigeminal nociceptors innervating meningeal tissues. Many of these nociceptors also contain vasoactive neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P. Release of neuropeptides and other functional properties are frequently examined using the cell bodies of trigeminal neurons as models of their sensory endings. Pathophysiological conditions cause phosphorylation, increased expression and trafficking of transient receptor potential (TRP) channels, neuropeptides and other mediators, which accelerate activation of nociceptive pathways. Since nociceptor activation may be a significant pathophysiological mechanism involved in both peripheral and central sensitization of the trigeminal nociceptive pathway, its contribution to the pathophysiology of primary headaches is more than likely. Metabolic disorders and medication-induced painful states are frequently associated with TRP receptor activation and may increase the risk for primary headaches. View Full-Text
Keywords: transient receptor potential vanilloid 1; transient receptor potential ankyrin 1; calcitonin gene-related peptide; primary headaches; trigeminal system; nociception transient receptor potential vanilloid 1; transient receptor potential ankyrin 1; calcitonin gene-related peptide; primary headaches; trigeminal system; nociception
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MDPI and ACS Style

Dux, M.; Rosta, J.; Messlinger, K. TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches. Int. J. Mol. Sci. 2020, 21, 342. https://doi.org/10.3390/ijms21010342

AMA Style

Dux M, Rosta J, Messlinger K. TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches. International Journal of Molecular Sciences. 2020; 21(1):342. https://doi.org/10.3390/ijms21010342

Chicago/Turabian Style

Dux, Mária; Rosta, Judit; Messlinger, Karl. 2020. "TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches" Int. J. Mol. Sci. 21, no. 1: 342. https://doi.org/10.3390/ijms21010342

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