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Molecules, Volume 30, Issue 21

November-1 2025 - 174 articles

Cover Story: Tryptophan derivatives play crucial roles in biology. Understanding how subtle structural modifications lead to different biological functions remains a fundamental challenge. Using state-of-the-art laser-ablation microwave spectroscopy, we unveil the conformational landscape of 3-indoleacetamide, a key intermediate in plant hormone biosynthesis. This molecule exhibits unprecedented structural rigidity—imposed by the acetamide group and a stabilizing N–H•••π interaction—adopting only one stable conformation, unlike related compounds such as serotonin and tryptamine, which display multiple states. Our findings reveal a compelling structure–function relationship and establish gas-phase spectroscopy as a powerful tool for understanding molecular recognition in enzyme-binding pockets. View this paper
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Articles (174)

  • Article
  • Open Access
453 Views
26 Pages

From Chains to Chromophores: Tailored Thermal and Linear/Nonlinear Optical Features of Asymmetric Pyrimidine—Coumarin Systems

  • Prescillia Nicolas,
  • Stephania Abdallah,
  • Dong Chen,
  • Giorgia Rizzi,
  • Olivier Jeannin,
  • Koen Clays,
  • Nathalie Bellec,
  • Belkis Bilgin-Eran,
  • Huriye Akdas-Kiliç and
  • Jean-Pierre Malval
  • + 2 authors

6 November 2025

Eleven novel asymmetric pyrimidine derivatives were synthesized. The pyrimidine core was functionalized with a coumarin chromophore and a pro-mesogenic fragment bearing either chiral or linear alkyl chains of variable length and substitution patterns...

  • Article
  • Open Access
515 Views
19 Pages

6 November 2025

Localized 1H magnetic resonance spectroscopy (MRS) is a powerful tool in pre-clinical and clinical neurological research, offering non-invasive insight into neurochemical composition in localized brain regions. Zebrafish (Danio rerio) are increasingl...

  • Article
  • Open Access
653 Views
20 Pages

The Action of Cannabidiol on Doxycycline Cytotoxicity in Human Cells—In Vitro Study

  • Lidia Radko,
  • Tatiana Wojciechowicz,
  • Oliwia Kończak,
  • Paula Żakowicz,
  • Oskar Łętowski,
  • Julia Salmanowicz and
  • Zuzanna Skrzypczak

6 November 2025

Improper use of drugs in both animal and human therapy, such as doxycycline (DOX), lead to the accumulation of residues in edible animal tissues as well as in the environment. Plant-derived compounds reduce the adverse effects of drugs. This study ai...

  • Article
  • Open Access
682 Views
19 Pages

Advances in Lycopene Production: From Natural Sources to Microbial Synthesis Using Yarrowia lipolytica

  • Paweł Moroz,
  • Aleksandra Bartusiak,
  • Julia Niewiadomska,
  • Kacper Szymański,
  • Tomasz Janek,
  • Anna Kancelista,
  • Anna Gliszczyńska and
  • Zbigniew Lazar

6 November 2025

Lycopene, a natural carotenoid with antioxidant and health-promoting properties, has attracted attention as a valuable compound for the food, pharmaceutical, and cosmetic industries. Conventional production methods based on plant extraction or chemic...

  • Review
  • Open Access
681 Views
26 Pages

6 November 2025

Pleurotus ostreatus, commonly known as the oyster mushroom, is a widely cultivated edible mushroom characterized by its nutritional value and health benefits. However, its large-scale production generates significant amounts of agro-industrial by-pro...

  • Review
  • Open Access
818 Views
31 Pages

Phytochemicals as Epigenetic Modulators in Chronic Diseases: Molecular Mechanisms

  • Daniel Cord,
  • Mirela Claudia Rîmbu,
  • Marius P. Iordache,
  • Radu Albulescu,
  • Sevinci Pop,
  • Cristiana Tanase and
  • Maria-Linda Popa

6 November 2025

Phytochemicals are plant-derived bioactive compounds with antioxidant, anti-inflammatory, and epigenetic modulatory effects that may contribute to the prevention and management of chronic diseases. This review synthesizes recent evidence on the molec...

  • Article
  • Open Access
460 Views
22 Pages

Interacting Quantum Atoms Analysis of Covalent and Collective Interactions in Single Elongated Carbon–Carbon Bonds

  • Antonio Bonesana-Espinoza,
  • José Manuel Guevara-Vela,
  • Evelio Francisco,
  • Tomás Rocha-Rinza and
  • Ángel Martín Pendás

6 November 2025

Chemical bonds among carbon atoms are central to chemistry. A general working principle regarding these interactions is that these contacts become stronger as the carbon atoms become closer to each other. Nevertheless, there are long, yet strong sing...

  • Review
  • Open Access
534 Views
22 Pages

Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications

  • Urszula Izabela Maciołek,
  • Małgorzata Kosińska-Pezda,
  • Tamara Martínez-Senra,
  • Sonia Losada-Barreiro and
  • Carlos Bravo-Díaz

6 November 2025

Flavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being,...

  • Article
  • Open Access
409 Views
20 Pages

Plasma-Activated CO2 Dissociation to CO in Presence of CeO2 Mesoporous Catalysts

  • Oleg V. Golubev,
  • Alexey A. Sadovnikov and
  • Anton L. Maximov

6 November 2025

The increasing atmospheric CO2 concentration is one of the major environmental challenges, necessitating not only emission reduction but also effective carbon utilization. Non-thermal plasma-catalytic CO2 conversion offers an efficient pathway under...

  • Article
  • Open Access
767 Views
21 Pages

Phytochemical Constituent of Devil Weed (Chromolaena odorata), Concurrent with Its Antioxidant, α-Glucosidase Inhibitory, and Antibacterial Activity

  • Anastasia Wheni Indrianingsih,
  • Muhammad F. F. Ahla,
  • Anjar Windarsih,
  • Suratno,
  • Tri Wiyono,
  • Eka Noviana,
  • Nurrulhidayah Ahmad Fadzhillah and
  • Ririn Nur Alfiani

6 November 2025

This study aimed to investigate the phytochemical constituents of C. odorata leaves and stems and to evaluate their antioxidant, total phenol, α-glucosidase, and antibacterial activities. Furthermore, liquid chromatography-high-resolution mass...

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Molecules - ISSN 1420-3049