2025 November-1 - 174 articles
Eleven novel asymmetric pyrimidine derivatives were synthesized. The pyrimidine core was functionalized with a coumarin chromophore and a pro-mesogenic fragment bearing either chiral or linear alkyl chains of variable length and substitution patterns...
Localized 1H magnetic resonance spectroscopy (MRS) is a powerful tool in pre-clinical and clinical neurological research, offering non-invasive insight into neurochemical composition in localized brain regions. Zebrafish (Danio rerio) are increasingl...
Improper use of drugs in both animal and human therapy, such as doxycycline (DOX), lead to the accumulation of residues in edible animal tissues as well as in the environment. Plant-derived compounds reduce the adverse effects of drugs. This study ai...
Lycopene, a natural carotenoid with antioxidant and health-promoting properties, has attracted attention as a valuable compound for the food, pharmaceutical, and cosmetic industries. Conventional production methods based on plant extraction or chemic...
Pleurotus ostreatus, commonly known as the oyster mushroom, is a widely cultivated edible mushroom characterized by its nutritional value and health benefits. However, its large-scale production generates significant amounts of agro-industrial by-pro...
Phytochemicals are plant-derived bioactive compounds with antioxidant, anti-inflammatory, and epigenetic modulatory effects that may contribute to the prevention and management of chronic diseases. This review synthesizes recent evidence on the molec...
Chemical bonds among carbon atoms are central to chemistry. A general working principle regarding these interactions is that these contacts become stronger as the carbon atoms become closer to each other. Nevertheless, there are long, yet strong sing...
Flavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being,...
The increasing atmospheric CO2 concentration is one of the major environmental challenges, necessitating not only emission reduction but also effective carbon utilization. Non-thermal plasma-catalytic CO2 conversion offers an efficient pathway under...
This study aimed to investigate the phytochemical constituents of C. odorata leaves and stems and to evaluate their antioxidant, total phenol, α-glucosidase, and antibacterial activities. Furthermore, liquid chromatography-high-resolution mass...
Torrefaction, a mild thermochemical pretreatment process, generates the fuel-torrefied biomass along with non-condensable and condensable gases. The latter can be condensed to yield a dark, viscous liquid called torrefaction condensate (TC). In this...
Hydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments. In this study, we systematically compared the catalytic behavior of C2- and C1-symmetric hydr...
This scoping review synthesized evidence from 2015 to 2025 on the anti-inflammatory and anticancer potential of pecan (Carya illinoinensis) kernel extracts, focusing on bioactive composition and cell signaling pathway modulation. Pecan kernels contai...
The widespread use of single-use plastics, particularly polyethylene (PE) and polypropylene (PP), has resulted in severe environmental pollution due to their durability and resistance to degradation. This report reviews current degradable alternative...
Racemosol, a natural phenolic compound, is known for its antimicrobial potential, yet experimental studies remain limited. In this study, two new racemosol derivatives (4 and 5) and four known compounds (1–3, 6) were isolated from the bark of B...
In this study, Fe2O3–TiO2 nanocomposites with different TiO2 contents (1–50%) were synthesized via a solvothermal method using pre-formed α-Fe2O3 nanoparticles as cores. We systematically evaluated the influence of TiO2 loading on t...
The selective hydrogenation of the C=O bond over the C=C bond in α,β-unsaturated aldehydes remains a well-known challenge. This work investigates the liquid-phase catalytic transfer hydrogenation of crotonaldehyde to crotyl alcohol over Re...
The molecular mechanism of the formation of 1,3-diaryl-5-nitropyrazoles via a CHCl3-elimination reaction was investigated using ωB97xD/6-31+G(d,p) (PCM) calculations. It was found that, regardless of the polarity of the reaction environment or...
The electrochemical oxidation mechanism of biopolymer lignin is challenging to characterize due to its complex structure. Controlling the oxidation process is crucial for ensuring the economic feasibility of electrochemical depolymerization of lignin...
Pulses and pseudocereals are sustainable protein sources of bioactive peptides (BAPs) with potential antioxidant, antihypertensive, antidiabetic, antimicrobial, and immunomodulatory activities. BAPs are typically liberated during gastrointestinal dig...
Interest in non-canonical DNA structures continues to grow, in part fueled by the recent discovery of a new structure, G-triplex DNA. Originally proposed as folding intermediates for G-quadruplex DNA, G-triplex DNA has more recently been shown to for...
Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity. By converting the spin or...
Sesquiterpenes are a diverse class of natural products that have garnered considerable interest for their potent bioactivity and structural variability. This review highlights advances in the derivatization of various sesquiterpene lactones, quinones...
This study examined the impact of distance from the road traffic on soil enzymatic activity, which we used as a tool to assess the relationship between soil and common nettle (Urtica dioica L.) used in herbalism and phytotherapy. A section of nationa...
Regulatory changes in the EU for safety purposes require strict control and high safety standards for essential oils obtained by steam distillation, as they are classified as chemical mixtures with potential toxic effects. Subcritical water extracts...
Nigella sativa, or black cumin, is used as a spice in cooking and as a food supplement like seeds or oil for its biological properties, including antioxidant capacity, anti-inflammatory action, and support for the immune system. In the present study,...
Acetaminophen (APAP) is a widely used pharmaceutical increasingly detected as a contaminant in aquatic environments due to its persistent nature and incomplete removal by conventional wastewater treatment. This study investigates the adsorption perfo...
Corn stover (CS) is an abundant biomaterial, which is regularly rejected during corn harvesting. This biowaste is a typical lignocellulosic source rich in hydroxycinnamates, which are mainly represented by p-coumaric acid and ferulic acid. These poly...
Several pieces of evidence have demonstrated the sigma-1 receptor (S1R) as a druggable protein with important therapeutic potentials, including neurodegeneration, cancer, and neuropathic pain. The density of S1R is altered in pathological processes s...
Passion fruit (Passiflora edulis f. flavicarpa), commonly known as yellow passion fruit, is widely grown across tropical and subtropical regions worldwide, with Brazil as one of the top producers. Mexico also produces a significant amount of this var...
Immune checkpoint inhibitors (ICIs) targeting PD-L1 and CD47 are clinically limited by severe off-target toxicities. To address this issue, immunotherapeutic prodrug strategies have been developed, aimed at preventing antibodies from binding to targe...
The increasing presence of antibiotics such as cephalosporins in wastewater represents a significant environmental risk. These compounds are excreted in large quantities, and conventional wastewater treatment plants are often ineffective at their rem...
The advent of nanotechnology has revolutionized the field of medicine, particularly in the development of targeted therapeutic strategies. Among these, radiolabeled nanomaterials have emerged as promising tools for both diagnostic and therapeutic app...
Water contamination has become a critical issue, resulting in a decline in global water quality that harms both human health and the environment. Biochar, a porous carbon-rich material produced through the thermochemical decomposition of biomass, has...
The electronic effects of Lewis acids (LAs) in reducing the activation energies of Alder-ene (AE) reactions have been studied within the Molecular Electron Density Theory (MEDT). To this end, the AE reactions of 2-methylbutadiene (2MBD) with formalde...
Vapor pressures of eight aliphatic hexanols ((±)-3-hexanol, CAS RN: 623-37-0; 2-methyl-2-pentanol, CAS RN: 590-36-3; (±)-2-methyl-3-pentanol, CAS RN: 565-67-3; (±)-3-methyl-2-pentanol, CAS RN: 565-60-6; 3-methyl-3-pentanol, CAS R...
Oxidative and glycation stress are interrelated pathological processes that significantly contribute to the development and progression of chronic diseases, including diabetes, chronic kidney disease, cardiovascular disorders, and neurodegenerative c...
The Ni/Al2O3 interface bears the load transfer and energy dissipation, which determines the service performance of the composite materials. In this study, three distinct vacancy-defect-modified interface models (D1, D2, and D3, corresponding to vacan...
Metathesis reactions of Ag[C(CN)3] with anhydrous YbCl3 dissolved in water combined with stoichiometric amounts of the alkali-metal salts A[C(CN)3] (A = Na or K) yield the non-isotypic tetragonal compounds NaYb[C(CN)3]4 (P4/nnc with a = 1188.37(9) pm...
To enhance the photocatalytic performance of TiO2 nanotubes (NTs) for the degradation of Amido Black as an organic pollutant, electrodeposition of bismuth vanadate (BiVO4) nanostructures was successfully applied. The effect of electrodeposited BiVO4...
This review summarizes the recent developments in titanium suboxide (TSO) doping and the application of doped materials in pollutant degradation and electrochemistry. Doping is mainly limited to transition and rare-earth metals, with some exceptions,...
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options, prompting extensive research into novel therapeutics. This study presents a comprehensive molecular characterization of usnic a...
This study introduces the preparation and tailoring of the catalytic properties of a novel biomass-based composite to produce a sustainable biolubricant, trimethylolpropane fatty acid triester (TFATE), via the transesterification of fatty acid methyl...
Background/Objectives: This study reports pilot-scale production of gluten-free rice malt extract powder from Thai Chainat 1 rice as a sustainable alternative to barley malt extract. Methods: The process combined controlled malting with sequential en...
RNA triple helices are relatively understudied, including their interactions with small molecules. In this study, we evaluated eight previously reported triplex-binding molecules (TBMs) for their functional effects on the premature and mature MALAT1...
c-Jun N-terminal kinase (JNK) activation has been shown to play a crucial role in the development of various types of cancer. IQ-1S is a JNK inhibitor based on the 11H-indeno[1,2-b]quinoxalin-11-one scaffold. The aim of this study was to investigate...
Andrographis paniculata, a medicinal plant widely found in Asia, contains andrographolide as its main active compound, known for its wide-ranging pharmacological effects, including anti-inflammatory, anti-cancer, anti-obesity, and anti-diabetic prope...
Ladle furnace (LF) refining is one of the most widely used secondary refining processes for producing clean steel and constitutes a key process in the steelmaking–continuous casting section. The properties of slag play a decisive role in determ...
Heavy metal ions in herbal medicine sometimes exceed the standard limit, inducing severe and harmful problems in human health. Exploring new nanomaterials to chelate heavy metal ions and reduce their concentration in herbal decoctions could be a solu...
Berberine hydrochloride, a bioactive isoquinoline alkaloid with metabolic, lipid-lowering, and antimicrobial properties, is increasingly synthesized for nutraceutical applications due to its high yield and, therefore, cost-effectiveness. However, syn...
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