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Synthesis, Properties, and Applications of Chiral Molecules

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1145

Special Issue Editor


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Guest Editor
Red de Estudios Moleculares Avanzados, Campus III, Instituto de Ecología A. C., Carretera Antigua a Coatepec 351, Xalapa 91073, Mexico
Interests: enantioselective catalysis; asymmetric synthesis; chiral bioactive compounds; organic chemistry

Special Issue Information

Dear Colleagues,

Chiral molecules, defined by their non-superimposable mirror images, play a foundational role in contemporary chemistry due to their prevalence in biological systems and their enantioselective interactions in chemical and biochemical processes. The synthesis, characterization, and application of these molecules continue to be areas of intense scientific interest, particularly in the development of pharmaceuticals, agrochemicals, and functional materials.

Recent advances in asymmetric catalysis, stereoselective synthesis, and computational modeling have enabled the precise design of chiral compounds with tailored properties. These innovations not only enhance synthetic efficiency, but also broaden the potential applications of chiral molecules in medicinal chemistry, materials science, and sustainable technologies.

This Special Issue, “Synthesis, Properties, and Applications of Chiral Molecules”, invites original research and review articles that explore recent developments in the field. Topics of interest include, but are not limited to, new methods for asymmetric synthesis, the characterization of chiral compounds, advances in chiral catalysts, and applications of chirality in drug discovery, molecular recognition, and catalysis.

We look forward to your contributions, which will allow us to highlight the multidisciplinary importance of chirality in science and technology.

Dr. José Luis Olivares-Romero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • asymmetric catalysis
  • new chiral catalyst
  • stereoselective synthesis of natural products and analogs
  • chiral auxiliaries and reagents
  • computational and mechanistic studies of chiral processes
  • stereochemical characterization (e.g., ECD, VCD, NMR, XRD)
  • chirality in pharmaceutical development (ADMET, enantioselective binding)
  • enantioselective recognition, sensors, and separation technologies
  • chiral materials in optoelectronics, polymers, and supramolecular chemistry
  • green and sustainable strategies for chiral synthesis

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Published Papers (1 paper)

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Research

13 pages, 1615 KB  
Article
A Comparative Study of C2-Symmetric and C1-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols
by Marco Valtierra-Galván, Alfredo Rodríguez-Hernández, Israel Bonilla-Landa, Felipe Barrera-Méndez, Francisco Javier Enríquez-Medrano, Ramón Enrique Díaz de León-Gómez and José Luis Olivares-Romero
Molecules 2025, 30(21), 4311; https://doi.org/10.3390/molecules30214311 - 6 Nov 2025
Cited by 1 | Viewed by 753
Abstract
Hydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments. In this study, we systematically compared the catalytic behavior of C2- and C1-symmetric hydroxamic acid ligands in the vanadium-catalyzed [...] Read more.
Hydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments. In this study, we systematically compared the catalytic behavior of C2- and C1-symmetric hydroxamic acid ligands in the vanadium-catalyzed asymmetric epoxidation of allylic alcohols. A series of chiral hydroxamic acids (HA1–HA7) was synthesized and evaluated under varied conditions to elucidate the influence of ligand symmetry on enantioinduction and reactivity. The results demonstrate that C2-symmetric bishydroxamic acids generate a highly organized chiral environment, leading to high enantioselectivity but often limited conversion, consistent with the Sabatier principle. Conversely, certain C1-symmetric ligands—particularly HA3—produced notable enantioselectivity (up to 71% e.e.) and full conversion under optimized conditions with VO(OiPr)3 in CH2Cl2. A quadrant-based stereochemical model is proposed to rationalize the differential performance of these ligands. These findings highlight the critical role of ligand desymmetrization in modulating the chiral environment around vanadium centers, providing valuable design principles for next-generation hydroxamic acid-based catalysts in asymmetric synthesis. The optimized system (VO(OiPr)3/HA3 in CH2Cl2) afforded >99% conversion and 71% e.e., providing a basis for extending hydroxamic acid scaffolds to diverse allylic alcohols. Full article
(This article belongs to the Special Issue Synthesis, Properties, and Applications of Chiral Molecules)
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