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Nanomaterials and Nanocomposites: Synthesis, Characterization and Applications in Environmental and Biomedical Sciences

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 325

Special Issue Editors


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Guest Editor
Centro Universitario de los Lagos, Universidad de Guadalajara, Lagos de Moreno, Mexico
Interests: nanostructured materials; noble metal nanoparticles; metal-oxide nanoparticles; adsorption; photocatalysis; antimicrobial applications
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Predio el Saucillo y el Potrero, Comunidad de los Tepetates, León 37684, Mexico
Interests: nanostructures; anticancer applications; cancer theranostics; antimicrobial applications; 3D cell models; biomaterials; 2D structures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on “Nanomaterials and Nanocomposites: Synthesis, Characterization and Applications in Environmental and Biomedical Sciences” invites scientific contributions such as research articles, communications, letters and reviews (systematic, narrative and scoping), highlighting new advances, techniques, functionalization and strategies for diverse applications of nanomaterials in environmental and biomedical fields. In recent years, nanomaterials have been developed for use in various biomedical applications using novel strategies. Along with biofunctionalization, these materials have been extensively studied due to their essential applications. However, there remain significant challenges; thus, many researchers are exploring innovative alternatives to develop nanomaterials with outstanding material properties to increase biocompatibility and enhance their potential for use in biomedicine.

On the other hand, due to increasing contaminants, environmental remediation requires continuous research efforts. Developing novel nanostructured materials, such as nanoadsorbents, nanocatalysts, membranes, and sensors, is essential for the removal, degradation, detection, and control of pollutants in different environmental media.

Dr. Rita Patakfalvi
Dr. Ravichandran Manisekaran
Guest Editors

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Keywords

  • nanomaterials
  • diagnostics
  • therapy
  • anticancer
  • antimicrobial
  • adsorption
  • photocatalysis
  • sensor

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Published Papers (1 paper)

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Research

12 pages, 1742 KiB  
Article
Therapeutic Effects of PSL-Loaded PLGA-PEG-PLGA NPs in Allergic Contact Dermatitis Model Mice
by Ryo Fujisawa, Ryuse Sakurai, Takeshi Oshizaka, Kenji Mori, Akiyoshi Saitoh, Issei Takeuchi and Kenji Sugibayashi
Molecules 2025, 30(15), 3292; https://doi.org/10.3390/molecules30153292 - 6 Aug 2025
Viewed by 106
Abstract
This study focused on the poly(DL-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(DL-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer, which was recently reported as a novel material for polymeric nanoparticles to replace poly(DL-lactide-co-glycolide) (PLGA) as a drug carrier for prednisolone (PSL), and [...] Read more.
This study focused on the poly(DL-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(DL-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer, which was recently reported as a novel material for polymeric nanoparticles to replace poly(DL-lactide-co-glycolide) (PLGA) as a drug carrier for prednisolone (PSL), and aimed to evaluate the efficacy of PSL-loaded PLGA-PEG-PLGA nanoparticles (NPs) against allergic contact dermatitis (ACD). PSL-loaded PLGA-PEG-PLGA NPs were prepared using the nanoprecipitation method, and their particle size distribution and mean particle size were measured using dynamic light scattering. 1-Fluoro-2,4-dinitrobenzene (DNFB) was used to create a mouse model of contact hypersensitivity (CHS). PSL-loaded PLGA-PEG-PLGA NPs were administered before sensitization with DNFB, and the therapeutic effect was evaluated by quantifying intracutaneous TNF-α and IL-4 levels suing ELISA. When PSL-loaded PLGA-PEG-PLGA NPs were administered before sensitization, TNF-α expression and IL-4 statements were significantly lower in the PSL-loaded PLGA-PEG-PLGA NP group than in the non-treated group. No significant difference was observed between the PSL-loaded PLGA-PEG-PLGA NP and PSL-loaded ointment groups, even though the steroid dose was 40 times lower than in the PSL-containing ointment. These results suggest that PSL-loaded PLGA-PEG-PLGA NPs may have a better effect in the treatment of ACD than PSL-loaded PLGA NPs. Full article
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