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Biologically Active Molecules: Extraction Strategies, Therapeutic Potential and Biomedical Perspective

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1027

Special Issue Editor

Special Issue Information

Dear Colleagues,

You are cordially invited to submit articles for inclusion in a new Special Issue covering a broad spectrum of research topics relating to biologically active molecules, including their isolation from plant materials, their therapeutic and biomedical profiling, and considerations of practical future applications to improve human health.

Advanced phytochemical techniques based on highly sophisticated scientific instrumentation have resulted in controlled and effective extraction strategies for isolating biologically active plant components and developing quality-controlled, validated analytical methods. This has paved the way for modern biological and pharmacological studies and the assessment of the therapeutic potential of both plant isolates and standardised herbal drug preparations.

The scope of this Special Issue will specifically focus on obtaining biologically active phytochemicals using traditional or assisted (including ultrasound or microwave-assisted and pressurised liquid) organic solvent extraction techniques, as well as those utilising green ecological extractants. Parallel to phytochemical studies, we welcome contributions underlining the biological or toxicological effects of herbal components and preparations, as well as research insights pointing to future directions for scientific research and suggestions for the biomedical/therapeutic application of natural products.

Dr. Grażyna Zgórka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural bioactive components
  • extraction techniques
  • therapeutic and biomedical profiling

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Published Papers (2 papers)

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Research

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22 pages, 2687 KiB  
Article
Isomeric 3-Pyridinylmethylcoumarins Differ in Erk1/2-Inhibition and Modulation of BV2 Microglia-Mediated Neuroinflammation
by Rami Schulzki, Matthias Apweiler, Caroline Röttger, Christoph W. Grathwol, Nora Struchtrup, Sophia Abou El Mirate, Claus Normann, Stefan Bräse and Bernd L. Fiebich
Molecules 2025, 30(11), 2452; https://doi.org/10.3390/molecules30112452 - 3 Jun 2025
Viewed by 310
Abstract
Coumarins are known for their multiple biological effects and have been established as anti-coagulative drugs for years. Furthermore, some coumarins can promote anti-inflammatory effects via the GPR55 receptor, and dual target coumarins have been synthesized. Anti-inflammatory drugs might be beneficial in the treatment [...] Read more.
Coumarins are known for their multiple biological effects and have been established as anti-coagulative drugs for years. Furthermore, some coumarins can promote anti-inflammatory effects via the GPR55 receptor, and dual target coumarins have been synthesized. Anti-inflammatory drugs might be beneficial in the treatment of neuropsychiatric disorders, as the inflammatory hypothesis suggests. For the current study, we compared isomeric 3-pyridinylmethylcoumarins with altered N-atom position regarding their effects on cytokine and chemokine synthesis and expression in LPS-stimulated BV2 microglial cells. The 3-pyridin-4-yl-methylcoumarin showed the most potent anti-inflammatory effects, followed by the 3-pyridin-2-ylmethylcoumarin analog. The observed effects might be mediated by an inhibition of ERK phosphorylation. Full article
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Review

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16 pages, 585 KiB  
Review
The Role of Lactoferrin in Combating Candida spp. Infections Through Regulation of Oxidative Stress, Immune Response, and Nutritional Support in Women and Newborns
by Anna Długosz, Joanna Wróblewska, Paweł Kołaczyk and Weronika Wróblewska
Molecules 2025, 30(11), 2416; https://doi.org/10.3390/molecules30112416 - 31 May 2025
Viewed by 488
Abstract
Lactoferrin (LF) is a natural glycoprotein with strong antimicrobial, immunomodulatory, and nutritional potential and is widely present in milk and mucosal secretions. This paper aims to review the current knowledge on the application of lactoferrin and its bioactive peptides in the context of [...] Read more.
Lactoferrin (LF) is a natural glycoprotein with strong antimicrobial, immunomodulatory, and nutritional potential and is widely present in milk and mucosal secretions. This paper aims to review the current knowledge on the application of lactoferrin and its bioactive peptides in the context of fungal infections caused by Candida spp., focusing on newborns and pregnant women as high-risk groups. The multifaceted mechanisms of LF action are discussed, including iron chelation, destabilization of fungal cell membranes, and modulation of the immune response. Additionally, data demonstrating the effectiveness of LF in the prevention and supportive treatment of Candida spp. infections are presented. Full article
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