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Molecules, Volume 28, Issue 4

February-2 2023 - 484 articles

Cover Story: The complexation abilities of cucurbiturils (CBs) could be enhanced with the assistance of metal cations, which can exert a dual effect on the complexation process: either by competitively binding to the host entity or cooperatively associating to the CB[n]-guest structures. The current study focuses on the role of two metal species (Mg2+ and Ga3+) in the complex formation of CBs with three dye molecules: Thiazole Orange, Neutral Red, and Thioflavin T. Various key factors influencing the process have been recognized such as the pH and dielectric constant of the medium, cavity size of the host, Mn+ charge, and presence/absence of hydration shell around the metal cation. The results obtained from density functional theory (DFT) calculations shed new light on several aspects of the cucurbituril complexation chemistry. View this paper
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Articles (484)

  • Article
  • Open Access
8 Citations
3,244 Views
15 Pages

68Ga-Labeled [Thz14]Bombesin(7–14) Analogs: Promising GRPR-Targeting Agonist PET Tracers with Low Pancreas Uptake

  • Lei Wang,
  • Ivica Jerolim Bratanovic,
  • Zhengxing Zhang,
  • Hsiou-Ting Kuo,
  • Helen Merkens,
  • Jutta Zeisler,
  • Chengcheng Zhang,
  • Ruiyan Tan,
  • François Bénard and
  • Kuo-Shyan Lin

20 February 2023

With overexpression in various cancers, the gastrin-releasing peptide receptor (GRPR) is a promising target for cancer imaging and therapy. However, the high pancreas uptake of reported GRPR-targeting radioligands limits their clinical application. O...

  • Review
  • Open Access
11 Citations
4,609 Views
20 Pages

20 February 2023

Owing to the rapid development of the cosmetic industry, cosmetic safety has become the focus of consumers’ attention. However, in order to achieve the desired effects in the short term, the illegal addition of hormones in cosmetics has emerged...

  • Article
  • Open Access
19 Citations
3,495 Views
13 Pages

Reversible Luminescent Switching Induced by Heat/Water Treatment in a Zero-Dimensional Hybrid Antimony(Ⅲ) Chloride

  • Ying-Chen Peng,
  • Hao-Wei Lin,
  • Sheng-Hua Zhou,
  • Jian-Ce Jin,
  • Ting-Hui Zhuang,
  • Abdusalam Ablez,
  • Ze-Ping Wang,
  • Ke-Zhao Du and
  • Xiao-Ying Huang

19 February 2023

Recently zero-dimensional (0-D) inorganic–organic metal halides (IOMHs) have become a promising class of optoelectronic materials. Herein, we report a new photoluminescent (PL) 0-D antimony(III)-based IOMH single crystal, namely [H2BPZ][SbCl5]&...

  • Article
  • Open Access
5 Citations
3,640 Views
12 Pages

Lactose and Galactose Promote the Crystallization of Human Galectin-10

  • Yu-Fan Fu,
  • Si-Cong Jiang,
  • Zhong-Wei Zhang,
  • Xin-Yue Yang,
  • Zi-Lin Li,
  • Jing Hu and
  • Shu Yuan

19 February 2023

Galectin-10 (Gal-10) forms Charcot–Leyden crystals (CLCs), which play a key role in the symptoms of asthma and allergies and some other diseases. Gal-10 has a carbohydrate-binding site; however, neither the Gal-10 dimer nor the CLCs can bind su...

  • Article
  • Open Access
1 Citations
2,417 Views
17 Pages

19 February 2023

Dipeptidyl peptidase III (DPP III), a zinc exopeptidase, is involved in the final steps of intercellular protein degradation and has a marked affinity for opioid peptides such as enkephalins and endomorphins. Recently, we characterized a number of ne...

  • Article
  • Open Access
6 Citations
2,727 Views
16 Pages

A Natural Glucan from Black Bean Inhibits Cancer Cell Proliferation via PI3K-Akt and MAPK Pathway

  • Peng Li,
  • Yihua Hu,
  • Lingmin Zhan,
  • Jiaqi He,
  • Jingwu Lu,
  • Chunyan Gao,
  • Weijun Du,
  • Aiqin Yue,
  • Jinzhong Zhao and
  • Wuxia Zhang

19 February 2023

A natural α-1,6-glucan named BBWPW was identified from black beans. Cell viability assay showed that BBWPW inhibited the proliferation of different cancer cells, especially HeLa cells. Flow cytometry analysis indicated that BBWPW suppressed the...

  • Article
  • Open Access
19 Citations
4,417 Views
15 Pages

Variation of Aroma Components of Pasteurized Yogurt with Different Process Combination before and after Aging by DHS/GC-O-MS

  • Mu Zhao,
  • Hongliang Li,
  • Dongjie Zhang,
  • Jie Li,
  • Rong Wen,
  • Hairan Ma,
  • Tingting Zou,
  • Yaqiong Hou and
  • Huanlu Song

19 February 2023

Pasteurized yogurt is a healthy yogurt that can be stored in ambient temperature conditions. Dynamic headspace sampling (DHS) combined with gas chromatography-olfactory mass spectrometry (GC-O-MS), sensory evaluation, electronic nose (E-nose), and pa...

  • Article
  • Open Access
1 Citations
2,406 Views
13 Pages

19 February 2023

Cinnamomum japonicum (CJ) is widely distributed in Asian countries like Korea, China, and Japan. Modern pharmacological studies have demonstrated that it exhibits various biological activities, including antioxidant and anti-inflammatory effects. How...

  • Review
  • Open Access
7 Citations
5,630 Views
35 Pages

The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors

  • Duong Tien Anh,
  • Nguyen Hai Nam,
  • Brigitte Kircher and
  • Daniel Baecker

19 February 2023

In recent years, histone deacetylases (HDACs) have emerged as promising targets in the treatment of cancer. The approach is to inhibit HDACs with drugs known as HDAC inhibitors (HDACis). Such HDACis are broadly classified according to their chemical...

  • Article
  • Open Access
16 Citations
5,544 Views
10 Pages

19 February 2023

Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer that occurs in hepatocytes. Although many chemical drugs, e.g., cisplatin, methotrexate, taxis, and doxorubicin are used to treat HCC, there have been numerous reports...

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Molecules - ISSN 1420-3049