Table of Contents
Molecules, Volume 24, Issue 16 (August-2 2019) – 163 articles
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Cover Story (view full-size image) Benzimidazoles are building blocks of great interest for the development of pharmacologically [...] Read more. Benzimidazoles are building blocks of great interest for the development of pharmacologically active compounds. For the first time, a type III active DES based on choline chloride and the HBD o-phenylenediamine (ChCl:o-PDA) were prepared and used as reaction media and reagents for the synthesis of 2-substituted or 1,2-disubstituted benzimidazole derivatives. The proposed method is a more ecofriendly approach for obtaining this “privileged nucleus”, even on a large scale, and perfectly fulfills the principles of green chemistry. View this paper