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Article

Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin

1
Department of Neuroscience, Psychology, Drug Research and Child Health—NEUROFARBA—Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy
2
CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 40128 Bologna, Italy
3
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
4
Interdepartmental Research Centre “Nutraceuticals and Food for Health (NUTRAFOOD)”, University of Pisa, 56126 Pisa, Italy
5
Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Pinarosa Avato
Molecules 2019, 24(16), 3006; https://doi.org/10.3390/molecules24163006
Received: 13 June 2019 / Revised: 2 August 2019 / Accepted: 7 August 2019 / Published: 19 August 2019
(This article belongs to the Special Issue Natural Products and Drug Discovery)
The management of pain in patients affected by diabetic neuropathy still represents an unmet therapeutic need. Recent data highlighted the pain-relieving efficacy of glucosinolates deriving from Brassicaceae. The purpose of this study was to evaluate the anti-hyperalgesic efficacy of Eruca sativa defatted seed meal, along with its main glucosinolate, glucoerucin (GER), on diabetic neuropathic pain induced in mice by streptozotocin (STZ). The mechanism of action was also investigated. Hypersensitivity was assessed by paw pressure and cold plate tests after the acute administration of the compounds. Once bio-activated by myrosinase, both E. sativa defatted meal (1 g kg−1 p.o.) and GER (100 µmol kg−1 p.o., equimolar to meal content) showed a dose-dependent pain-relieving effect in STZ-diabetic mice, but the meal was more effective than the glucosinolate. The co-administration with H2S scavengers abolished the pain relief mediated by both E. sativa meal and GER. Their effect was also prevented by selectively blocking Kv7 potassium channels. Repeated treatments with E. sativa meal did not induce tolerance to the anti-hypersensitive effect. In conclusion, E. sativa meal can be suggested as a new nutraceutical tool for pain relief in patients with diabetic neuropathy. View Full-Text
Keywords: diabetic neuropathy; neuropathic pain; glucosinolates; Eruca sativa; glucoerucin; H2S; Kv7 potassium channels diabetic neuropathy; neuropathic pain; glucosinolates; Eruca sativa; glucoerucin; H2S; Kv7 potassium channels
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MDPI and ACS Style

Lucarini, E.; Pagnotta, E.; Micheli, L.; Parisio, C.; Testai, L.; Martelli, A.; Calderone, V.; Matteo, R.; Lazzeri, L.; Di Cesare Mannelli, L.; Ghelardini, C. Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin. Molecules 2019, 24, 3006. https://doi.org/10.3390/molecules24163006

AMA Style

Lucarini E, Pagnotta E, Micheli L, Parisio C, Testai L, Martelli A, Calderone V, Matteo R, Lazzeri L, Di Cesare Mannelli L, Ghelardini C. Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin. Molecules. 2019; 24(16):3006. https://doi.org/10.3390/molecules24163006

Chicago/Turabian Style

Lucarini, Elena; Pagnotta, Eleonora; Micheli, Laura; Parisio, Carmen; Testai, Lara; Martelli, Alma; Calderone, Vincenzo; Matteo, Roberto; Lazzeri, Luca; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla. 2019. "Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin" Molecules 24, no. 16: 3006. https://doi.org/10.3390/molecules24163006

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