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Open AccessArticle

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites

1
Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China
2
National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun 130118, China
3
School of Pharmaceutical Sciences Changchun University of Chinese Medicine, Changchun 130117, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(16), 2985; https://doi.org/10.3390/molecules24162985
Received: 23 July 2019 / Revised: 14 August 2019 / Accepted: 15 August 2019 / Published: 17 August 2019
(This article belongs to the Section Natural Products Chemistry)
Ginsenoside Ro (Ro), a major saponin derived and isolated from Panax ginseng C.A. Meyer, exerts multiple biological activities. However, the anti-tumour efficacy of Ro remains unclear because of its poor in vitro effects. In this study, we confirmed that Ro has no anti-tumour activity in vitro. We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. Zingibroside R1, chikusetsusaponin IVa, and calenduloside E, three metabolites of Ro, were detected in the plasma of Ro-treated tumour-bearing mice and showed excellent anti-tumour effects as well as anti-angiogenic activity. The results suggest that the metabolites play important roles in the anti-tumour efficacy of Ro in vivo. Additionally, the haemolysis test demonstrated that Ro has good biocompatibility. Taken together, the findings of this study demonstrate that Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo, and its anti-tumour effects are based on the biological activity of its metabolites. The anti-tumour efficacy of these metabolites is due, at least in part, to its anti-angiogenic activity. View Full-Text
Keywords: ginsenoside Ro; metabolites; anti-tumour; B16F10 ginsenoside Ro; metabolites; anti-tumour; B16F10
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MDPI and ACS Style

Zheng, S.-w.; Xiao, S.-y.; Wang, J.; Hou, W.; Wang, Y.-p. Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites. Molecules 2019, 24, 2985. https://doi.org/10.3390/molecules24162985

AMA Style

Zheng S-w, Xiao S-y, Wang J, Hou W, Wang Y-p. Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites. Molecules. 2019; 24(16):2985. https://doi.org/10.3390/molecules24162985

Chicago/Turabian Style

Zheng, Si-wen; Xiao, Sheng-yuan; Wang, Jia; Hou, Wei; Wang, Ying-ping. 2019. "Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites" Molecules 24, no. 16: 2985. https://doi.org/10.3390/molecules24162985

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